0000000000654483

AUTHOR

Philip Robinson

showing 3 related works from this author

Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

2018

IF 3.756; International audience; De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was app…

AdultMaleAlcoholic liver diseasemedicine.medical_specialtyTime Factorsmedicine.medical_treatmentPopulation[SDV.CAN]Life Sciences [q-bio]/Cancer030230 surgeryLiver transplantationGastroenterologyRisk AssessmentLiver transplantation (LT)End Stage Liver Disease03 medical and health sciences0302 clinical medicinePostoperative ComplicationsRisk FactorsInternal medicineNeoplasmsmedicineHumanseducationLiver Diseases AlcoholicTransplantationeducation.field_of_studyHepatologybusiness.industryIncidence (epidemiology)IncidenceAbsolute risk reductionMiddle Agedmedicine.diseaseConfidence interval3. Good healthLiver TransplantationStandardized mortality ratioTreatment Outcome030211 gastroenterology & hepatologySurgeryFemaleFranceRisk assessmentbusinessFollow-Up Studies
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Disease-associated polymorphisms in ERAP1 do not alter endoplasmic reticulum stress in patients with ankylosing spondylitis

2014

The mechanism by which human leukocyte antigen B27 (HLA-B27) contributes to ankylosing spondylitis (AS) remains unclear. Genetic studies demonstrate that association with and interaction between polymorphisms of endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA-B27 influence the risk of AS. It has been hypothesised that ERAP1-mediated HLA-B27 misfolding increases endoplasmic reticulum (ER) stress, driving an interleukin (IL) 23-dependent, pro-inflammatory immune response. We tested the hypothesis that AS-risk ERAP1 variants increase ER-stress and concomitant pro-inflammatory cytokine production in HLA-B27(+) but not HLA-B27(-) AS patients or controls. Forty-nine AS cases and 22 healthy…

AdultMaleAnkylosing Spondylitismedicine.medical_treatmentImmunologyInflammationSingle-nucleotide polymorphismDiseaseBiologyERAP1AminopeptidasesPolymorphism Single NucleotideMinor Histocompatibility AntigensYoung AdultGene expressionGeneticsmedicineHumansSpondylitis AnkylosingERAP1 Ankylosing SpondylitisEndoplasmic Reticulum Chaperone BiPSpondylitisHLA-B27 AntigenGenetics (clinical)InflammationAnkylosing spondylitisEndoplasmic reticulumMiddle AgedEndoplasmic Reticulum Stressmedicine.diseaseCytokineImmunologyFemalemedicine.symptomGenes & Immunity
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Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

2015

Objective Ankylosing spondylitis (AS) is a common, highly heritable immune-mediated arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely ubiquitous environmental trigger. There is a close relationship between the gut and spondyloarthritis, as exemplified in patients with reactive arthritis, in whom a typically self-limiting arthropathy follows either a gastrointestinal or urogenital infection. Microbial involvement in AS has been suggested; however, no definitive link has been established. The aim of this study was to determine whether the gut in patients with AS carries a distinct microbial signature compared with that in the gut of healthy contro…

RikenellaceaebiologyImmunologyLachnospiraceaePorphyromonadaceaeIleumPrevotellaceaebiology.organism_classificationmedicine.diseasemedicine.anatomical_structureRheumatologyImmunologymedicineImmunology and AllergyReactive arthritisDysbiosisBacteroidaceaeArthritis & Rheumatology
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