0000000000654531

AUTHOR

Anthony J. Alberg

showing 2 related works from this author

Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma.

2006

BACKGROUND Classic Kaposi sarcoma (CKS) is an inflammatory-mediated neoplasm that develops in the presence of KS-associated herpesvirus (KSHV) and immune perturbation. In the current study, the authors compared CKS cases with age-matched and sex-matched KSHV-seropositive controls without human immunodeficiency virus-1 infection and markers of viral control, blood counts, CD4-positive and CD8-positive lymphocytes, and serum β-2-microglobulin and neopterin levels. METHODS Viral loads were detected using real-time amplification of the KSHV-K6 and EBV-pol genes, anti-K8.1 (lytic) titers were detected by enzyme-linked immunoadsorbent assay, and antilatent nuclear antigen (LANA) titers were detec…

AdultMaleCancer ResearchHIV InfectionsHematocritmedicine.disease_causePeripheral blood mononuclear cellHerpesviridaechemistry.chemical_compoundAntigenRisk FactorsmedicineGammaherpesvirinaeHumansSarcoma KaposiAgedAged 80 and overmedicine.diagnostic_testbiologybusiness.industryAntibody titerNeopterinMiddle Agedbiology.organism_classificationKaposi Sarcoma human herpesvirus-8 immunityOncologychemistryItalyImmunologyMultivariate AnalysisDisease ProgressionHIV-1FemalebusinessViral loadBiomarkersCancer
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A Common Genetic Variant inFCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma

2005

Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome – associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-V158F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANAseronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II…

AdultMaleEpidemiologyPopulationmedicine.disease_causeVirusHerpesviridaeAcquired immunodeficiency syndrome (AIDS)Risk FactorsOdds RatiomedicineHumansRisk factoreducationSarcoma KaposiAgedAged 80 and overeducation.field_of_studyClassic Kaposi Sarcomabusiness.industryReceptors IgGCase-control studyGenetic Variationvirus diseasesHerpesviridae InfectionsOdds ratioMiddle Agedmedicine.diseaseVirologyItalyOncologyCase-Control StudiesHerpesvirus 8 HumanImmunologybusinessCancer Epidemiology, Biomarkers & Prevention
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