0000000000654629

AUTHOR

José A. Esteban

showing 2 related works from this author

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

2016

Dyshomeostasis of amyloid-β peptide (Aβ) is responsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-blown dementia in Alzheimer's disease. Aβ appears to skew synaptic plasticity events toward depression. We found that inhibition of PTEN, a lipid phosphatase that is essential to long-term depression, rescued normal synaptic function and cognition in cellular and animal models of Alzheimer's disease. Conversely, transgenic mice that overexpressed PTEN displayed synaptic depression that mimicked and occluded Aβ-induced depression. Mechanistically, Aβ triggers a PDZ-dependent recruitment of PTEN into the postsynaptic compartment. Using a PTEN kno…

0301 basic medicinePrimary Cell CulturePDZ DomainsMice TransgenicMolecular neuroscienceBiologyNeurotransmissionSynaptic TransmissionMice03 medical and health sciences0302 clinical medicineAlzheimer DiseasePostsynaptic potentialmedicineAnimalsPTENGene Knock-In TechniquesAmyloid beta-PeptidesGeneral NeurosciencePTEN PhosphohydrolaseLong-term potentiationmedicine.diseaseRatsDisease Models Animal030104 developmental biologySynaptic fatigueSynaptic plasticitybiology.proteinAlzheimer's diseaseCognition DisordersNeuroscience030217 neurology & neurosurgeryNature Neuroscience
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Building Bridges through Science

2017

WOS: 000415310800007 PubMed ID: 29144972 Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched "The Science Bridge'' initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities. Medical Research Council [MC_UP_1202/5]

Historyhistory 15th centuryhistory 21st centuryhistory medievalInternational CooperationNeurophysiologyEurope; history 15th century; history 21st century; history ancient; history medieval; humans; middle east; neurosciences; international cooperation; neuroscience (all)Bridge (interpersonal)History 21st CenturyAncient03 medical and health sciencesMiddle East0302 clinical medicinehistory ancientPolitical scienceHumansThrough ScienceHistory AncientHistory 15th CenturyEurope; History 15th Century; History 21st Century; History Ancient; History Medieval; Humans; Middle East; Neurosciences; International Cooperation; Neuroscience (all)Neuroscience (all)General NeuroscienceBuilding BridgesNeurosciences21st CenturyHistory Medieval030227 psychiatry3. Good healthEurope15th CenturyGeneral partnershipEngineering ethics030217 neurology & neurosurgeryMedieval
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