0000000000659021

AUTHOR

Heike Lorenz

showing 7 related works from this author

Single Enantiomer’s Urge to Crystallize in Centrosymmetric Space Groups: Solid Solutions of Phenylpiracetam

2017

A detailed thermochemical and structural study of the phenylpiracetam enantiomer system was performed by characterizing the solid solutions, rationalizing the structural driving force for their formation, as well as identifying a common structural origin responsible for the formation of solid solutions of enantiomers. Enantiomerically pure phenylpiracetam forms two enantiotropically related polymorphs (enant–A and enant–B). The transition point (70(7) °C) was determined based on isobaric heat capacity measurements. Structural studies revealed that enant–A and enant–B crystallize in space groups P1 (Z′ = 4) and P212121 (Z′ = 2), respectively. However, pseudoinversion centers were present res…

010405 organic chemistryChemistrySpace groupGeneral Chemistry010402 general chemistryCondensed Matter PhysicsCentrosymmetry01 natural sciencesMiscibilityHeat capacity0104 chemical sciencesCrystallographyTransition pointIsobaric processGeneral Materials ScienceEnantiomerSolid solutionCrystal Growth & Design
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A Maze of Solid Solutions of Pimobendan Enantiomers: An Extraordinary Case of Polymorph and Solvate Diversity

2017

Over 10 polymorphs and solvatomorphs of the chiral pharmaceutically active ingredient pimobendan were found to lack enantioselectivity in the solid state, accordingly, forming solid solutions of enantiomers, which is reported to be a rare phenomenon. Solid form screening was performed on different enantiomeric composition samples to analyze obtained phases with powder X-ray diffraction and thermogravimetric differential scanning calorimetry. For nonsolvated forms, a melt phase diagram has been constructed convincingly showing the existence of stable and metastable solid solutions near the pure enantiomer and around the racemic composition regions. A crystal structure study combined with sol…

Thermogravimetric analysisMaterials science02 engineering and technologyGeneral ChemistryCrystal structure010402 general chemistry021001 nanoscience & nanotechnologyCondensed Matter Physics01 natural sciences0104 chemical sciencesCrystallographyDifferential scanning calorimetryPimobendanMetastabilitymedicineGeneral Materials ScienceEnantiomer0210 nano-technologyPhase diagramSolid solutionmedicine.drug
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CCDC 1523462: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Agris Be̅rziņš, Lia̅na Orola Tamás Holczbauer, Andris Actinš, Andreas Seidel-Morgenstern, Heike Lorenz|2017|Cryst.Growth Des.|17|1411|doi:10.1021/acs.cgd.6b01867

Space GroupCrystallographyCrystal SystemCrystal Structure2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamideCell ParametersExperimental 3D Coordinates
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CCDC 1050684: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Agris Be¯rzinš, Inese Sarcevica, Artis Kons, Ma¯rtinš Balodis, Lia¯na Orola, Heike Lorenz, Andris Actinš|2018|Cryst.Growth Des.|18|264|doi:10.1021/acs.cgd.7b01203

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parametersrac-6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-45-dihydropyridazin-3(2H)-oneExperimental 3D Coordinates
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CCDC 1571124: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Agris Be¯rzinš, Inese Sarcevica, Artis Kons, Ma¯rtinš Balodis, Lia¯na Orola, Heike Lorenz, Andris Actinš|2018|Cryst.Growth Des.|18|264|doi:10.1021/acs.cgd.7b01203

6-(2-(4-methoxyphenyl)-1H-benzimidazol-5-yl)-5-methyl-45-dihydropyridazin-3(2H)-oneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1523460: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Agris Be̅rziņš, Lia̅na Orola Tamás Holczbauer, Andris Actinš, Andreas Seidel-Morgenstern, Heike Lorenz|2017|Cryst.Growth Des.|17|1411|doi:10.1021/acs.cgd.6b01867

Space GroupCrystallographyCrystal SystemCrystal Structure2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamideCell ParametersExperimental 3D Coordinates
researchProduct

CCDC 1523461: Experimental Crystal Structure Determination

2017

Related Article: Toms Rekis, Agris Be̅rziņš, Lia̅na Orola Tamás Holczbauer, Andris Actinš, Andreas Seidel-Morgenstern, Heike Lorenz|2017|Cryst.Growth Des.|17|1411|doi:10.1021/acs.cgd.6b01867

Space GroupCrystallographyCrystal SystemCrystal Structure2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamideCell ParametersExperimental 3D Coordinates
researchProduct