0000000000661172

AUTHOR

B. Jacob

showing 2 related works from this author

Xenotransplantation of parathyroids in rats using barium-alginate and polyacrylic acid multilayer microcapsules

2001

The integrity and function of encapsulated parathyroid tissue following xenotransplantation is limited by oxygen and nutrition supply and capsule fibrosis. Since some of these factors depend on stability and biocompatibility of the coating material, multilayer microcapsules have been developed. Parathyroid tissue pieces and digested single cells from pigs were encapsulated in barium-alginate and in polyacrylic acid (PAA) multilayer capsules. After 7 days of culture the function of the encapsulated cells were assessed. Subsequently, in a part of the cultured microcapsules the viability was directly assessed whereas the other part was transplanted in dark animal [DA] rats for 30 days. After e…

NecrosisBiocompatibilityAlginatesCell SurvivalSwineBarium CompoundsTransplantation HeterologousAcrylic ResinsConnective tissueParathyroid hormoneToxicologyPathology and Forensic MedicineParathyroid Glandschemistry.chemical_compoundDrug Delivery SystemsCoated Materials BiocompatibleGlucuronic AcidIn vivoFibrosismedicineAnimalsCells CulturedChemistryHexuronic AcidsGraft SurvivalCapsuleCell BiologyGeneral MedicineAnatomymedicine.diseaseGlucuronic acidMolecular biologyRatsmedicine.anatomical_structureParathyroid Hormonemedicine.symptomExperimental and Toxicologic Pathology
researchProduct

Effect of media composition on long-term in vitro stability of barium alginate and polyacrylic acid multilayer microcapsules.

2000

For a number of applications stability of microcapsules is a critical factor. Since the maintenance of polyelectrolyte complexes depends considerably on the ion composition we tested the physical properties of barium alginate capsules and searched for conditions to improve stability by a multilayer coating with polyethylenimine (PEI) and polyacrylic acid (PAA). Mechanical stability and diameters were determined in barium alginate capsules and compared with multilayer capsules. Multilayer coating resulted in smaller capsules than barium complexing alone. The difference was more pronounced when CaCl2 was used instead of NaCl during coating. Barium alginate capsules and application of CaCl2 du…

Materials scienceAlginatesBiophysicsAcrylic Resinschemistry.chemical_elementBioengineeringBiocompatible MaterialsCapsulesengineering.materialPermeabilityBiomaterialschemistry.chemical_compoundCoatingCoated Materials BiocompatibleDrug StabilityPolymer chemistrySodium citratePolyethyleneiminePolyethyleniminePolyacrylic acidCapsuleBariumPolyelectrolyteCulture MediachemistryChemical engineeringDistilled waterMechanics of MaterialsCeramics and CompositesengineeringStress MechanicalBiomaterials
researchProduct