Expression of Human Ubiquitous Aquaporins in Chorial Villus Samples

2011

Background/objectives: Aquaporins (AQPs) are a family of proteins (AQP0-12) ubiquitously expressed acting as cell membrane water channels. AQP 1/3/8/9 expression has been found in human placenta and fetal membranes; however, AQP4 is the only identified in first trimester fetal tissue samples. We aimed to determine AQP mRNA expression in first trimester of pregnancy and compare it to the expression in placenta at delivery. Material and Methods: 26 Chorionic villus (CV) samples and 5 placental samples were collected and analyzed by real time-PCR using Taqman assay (Applied Biosystems®) for human AQP1, 2, 3, 4, 5, 6, 7, 8, 9, 11 and 18S. Results: CV expressed high mRNA levels of AQP1, 3, 9 and…