0000000000666989
AUTHOR
M. Castillo
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Biological Activities of Natural Sesquiterpene Lactones and the Effect of Synthetic Sesquiterpene Derivatives on Insect Juvenile Hormone Biosynthesis
Three natural sesquiterpene lactones have been assayed for their biological activity on locust (Locusta migratoria) nymphs. Since results obtained in vivo pointed to disruptions on juvenile hormone (JH)-regulated physiology, we tested the sesquiterpene lactones and a family of synthetic sesquiterpene derivatives for their ability to disturb the rate of JH biosynthesis by locust corpora allata (CA) in vitro. All the active compounds in vitro share a basic sesquiterpene double-ring structure as well as substituents with different chemical complexities. Compounds that shared an eudesmane base with different oxidation states on C3 and C12 carbon atoms were tested as JH biosynthesis inhibitors. …