0000000000667923

AUTHOR

Katy Maguin-gaté

showing 1 related works from this author

Physical training and hypertension have opposite effects on endothelial brain-derived neurotrophic factor expression

2013

AIMS: Changes in circulating brain-derived neurotrophic factor (BDNF) levels were reported in patients with or at risk for cardiovascular diseases associated with endothelial dysfunction, suggesting a link between BDNF and endothelial functionality. However, little is known on cardiovascular BDNF. Our aim was to investigate levels/localization, function, and relevance of cardiovascular BDNF. METHODS AND RESULTS: BDNF levels (western blotting) and localization (immunostaining) were assessed in the heart and aorta from rats with impaired (spontaneously hypertensive rats [SHR]), normal (Wistar Kyoto rats [WKY]), and improved (SHR and WKY subjected to physical training) endothelial function. BD…

MaleTime FactorsPhysiologyAorta ThoracicRats Inbred WKYVentricular Function Left0302 clinical medicineNeurotrophic factorsRats Inbred SHRMedicineEndothelial dysfunctionCells CulturedComputingMilieux_MISCELLANEOUS0303 health sciences[SDV.BA]Life Sciences [q-bio]/Animal biologyCoronary VesselsVasodilationmedicine.anatomical_structureHypertensioncardiovascular systemCardiology and Cardiovascular Medicinemedicine.medical_specialtyCell typeEndotheliumContractility03 medical and health sciencesCoronary CirculationPhysical Conditioning AnimalPhysiology (medical)Internal medicinemedicine.arteryVentricular PressureAnimals030304 developmental biologyBrain-derived neurotrophic factorAortabusiness.industryBrain-Derived Neurotrophic FactorEndothelial Cellsmedicine.diseaseMyocardial ContractionRatsDisease Models AnimalEndocrinologynervous systemRegional Blood FlowStress Mechanicalbusiness030217 neurology & neurosurgeryImmunostaining
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