Conformational equilibrium and intramolecular hydrogen bond of 4′X and 4X substituted 2′(OH)chalcones

1999

Abstract By using the AM1 method on 4X and 4′X substituted 2′(OH)chalcones (X=H, OH, F, Cl, CH 3 , CH 3 O, N(CH 3 ) 2 , and NO 2 ), certain currently unclear structural characteristics, conformational equilibria, intramolecular hydrogen bonds and UV spectroscopic properties had been clarified. The compounds studied have non-planar structures. The 2′(OH),4′Xchalcones only present the trans - s - cis conformation. trans - s - cis and trans - s - trans conformers of 2′(OH),4X-chalcones have a comparable thermodynamic stability. For these chalcones, a conformational equilibrium at 298 K exists, with 91% of the trans - s - cis form. The proposal of analyzing the intramolecular hydrogen bond of 2…