0000000000671375
AUTHOR
Danielle Menosi Gualandro
Effect of comprehensive vasodilation vs usual care on mortality and heart failure rehospitalization in women with acute heart failure
Abstract Background Guidelines recommend evaluating the risk/benefit ratio of novel therapies individually in women and men, as the pathophysiology and the response to treatment may differ between women and men. Among patients with acute heart failure (AHF), a strategy of intensive vasodilation, compared with usual care, overall did provide comparable outcomes. Purpose To evaluate the effect of a strategy that emphasized early intensive and sustained vasodilation in women with AHF. Methods In a randomized, open-label blinded-end-point trial patients hospitalized for AHF were enrolled in 10 hospitals in Switzerland, Bulgaria, Germany, Brazil, and Spain. Inclusion criteria were AHF expressed …
Der GALACTIC-Trial
Ziel der Studie ist zu untersuchen, ob bei normo- bis hypertensiver akuter Herzinsuffizienz eine therapeutische Strategie, basierend auf einer fruhen, zielgerichteten Senkung der Vor- und Nachlast mittels aggressiver Vasodilatation, in einem nicht-ICU-Setting sicher durchgefuhrt werden kann, und ob dies zu einer Verbesserung der Symptomatik und Prognose fuhrt.