0000000000672067

AUTHOR

Arto Pietilä

showing 4 related works from this author

The validity of heart failure diagnoses in the Finnish Hospital Discharge Register.

2019

Background: Contemporary validation studies of register-based heart failure diagnoses based on current guidelines and complete clinical data are lacking in Finland and internationally. Our objective was to assess the positive and negative predictive values of heart failure diagnoses in a nationwide hospital discharge register. Methods: Using Finnish Hospital Discharge Register data from 2013–2015, we obtained the medical records for 120 patients with a register-based diagnosis for heart failure (cases) and for 120 patients with a predisposing condition for heart failure, but without a heart failure diagnosis (controls). The medical records of all patients were assessed by a physician who c…

Malemedicine.medical_specialty030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicinePositive predicative valuemedicineHospital dischargeHumans030212 general & internal medicineRegistriesMedical diagnosisFinlandAgedHeart FailureEjection fractionbusiness.industryMedical recordPublic Health Environmental and Occupational HealthReproducibility of ResultsGeneral MedicineMiddle Agedmedicine.diseasePatient Discharge3. Good healthRegister (music)Register dataHeart failureEmergency medicineFemalebusinessScandinavian journal of public health
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Genetic variation of the interleukin-1 family and nongenetic factors determining the interleukin-1 receptor antagonist phenotypes.

2009

The natural anti-inflammatory protein interleukin-1 receptor antagonist (IL-1Ra) inhibits the activity of IL-1 and is associated with vascular injury and metabolic disorders. We analyzed genetic and nongenetic determinants of the IL-1Ra phenotype. Fifteen haplotype-tagging single nucleotide polymorphisms (SNPs) in the IL-1α (IL1A), IL-1β (IL1B), and IL-1 receptor antagonist (IL-1RN) genes were determined in the Health 2000 survey (n = 6771) and European myocardial infarction (MI) survivors (n = 972). Three SNPs were genotyped in the FINRISK97 (FR97) study (n = 7222). We found 3 IL1RN variants that were associated with the IL-1Ra phenotype in the study populations and remained significant af…

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismMyocardial InfarctionSingle-nucleotide polymorphism030204 cardiovascular system & hematologyBiologyPolymorphism Single Nucleotide03 medical and health sciences0302 clinical medicineEndocrinologyGene FrequencyMeta-Analysis as TopicInternal medicineGenetic variationmedicineHumansLongitudinal StudiesSurvivorsAllele frequency030304 developmental biologyAged2. Zero hungerGenetics0303 health sciencesGenetic VariationMiddle AgedExplained variation3. Good healthMinor allele frequencyInterleukin 1 Receptor Antagonist ProteinInterleukin 1 receptor antagonistEndocrinologyPhenotypeIL1AMultigene FamilyFemaleBody mass indexInterleukin-1Metabolism: clinical and experimental
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Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes

2011

Abstract.  Luotola K, Pietila A, Zeller T, Moilanen L, Kahonen M, Nieminen MS, Kesaniemi YA, Blankenberg S, Jula A, Perola M, Salomaa V (Helsinki University Hospital, Helsinki; National Institute for Health and Welfare, Helsinki, Finland; University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany; University Hospital of Kuopio, Kuopio; Tampere University Hospital and Medical School, University of Tampere, Tampere; University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu; National Institute for Health and Welfare, Turku; and Institute for Molecular Medicine Finland, Helsinki, Finland). Associations between interleukin-1 (IL-1) gene variations …

2. Zero hungerGerontology0303 health sciencesmedicine.medical_specialtybusiness.industryHazard ratio030209 endocrinology & metabolismType 2 diabetesmedicine.disease3. Good health03 medical and health sciences0302 clinical medicineDiabetes mellitusInternal medicineEpidemiologyCohortInternal MedicinemedicineMetabolic syndromebusinessBody mass index030304 developmental biologyCohort studyJournal of Internal Medicine
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HFvalidsupplement_210319_SJPH – Supplemental material for The validity of heart failure diagnoses in the Finnish Hospital Discharge Register

2019

Supplemental material, HFvalidsupplement_210319_SJPH for The validity of heart failure diagnoses in the Finnish Hospital Discharge Register by Matti A. Vuori, Jari A. Laukkanen, Arto Pietilä, Aki S. Havulinna, Mika Kähönen, Veikko Salomaa and Teemu J. Niiranen in Scandinavian Journal of Public Health

111799 Public Health and Health Services not elsewhere classifiedFOS: Health sciences
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