0000000000675500
AUTHOR
José Remohí Giménez
Reproductive outcomes after hysteroscopic metroplasty for women with dysmorphic uterus and recurrent implantation failure
The aim of this study was to assess the reproductive outcomes of women with recurrent implantation failure (RIF) after hysteroscopic metroplasty for dysmorphic uteri. Methods: This retrospective observational study included 190 women with a diagnosis of RIF. These patients were eligible for hysteroscopic metroplasty for dysmorphic uteri, including T-shaped uteri, between January 2008 and September 2015 at the Instituto Valenciano de Infertilidad (IVI) in Valencia, Spain. Results: The total clinical pregnancy rate, the live birth rate, and the abortion rate were 80.0% (152/190), 77.9% (147/190) and 8.9%, respectively. At 12 months, the clinical pregnancy rate was 76.3% (145/190) and at 6 mon…
Evaluation of a possible association between estradiol and progesterone levels and ectopic pregnancy in low risk women undergoing IVF/ICSI
Introduction: Several independent risk factors of Ectopic Pregnancy (EP) have been described to date. Nevertheless, estradiol and progesterone have not been related to ectopic pregnancy, although there is biological rationale to think about them as possible candidates. Our aim was to correlate the incidence of EP with levels of estradiol (E2) and progesterone (P4), measured on two days (hCG day, and seven days later (hCG+7)), including the differences and ratios of these concentrations, between the two time-points. Material and methods: Retrospective cohort study of 578 patients undergoing fresh embryo transfer after IVF (100 cycles), ICSI (508 cycles) and IVF/ICSI (64 cycles) without risk …
Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa
Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA. The plasma membrane of the sperm cell, which has high levels of polyunsaturated fatty acids, renders it particularly sensitive to free radical–mediated attacks. The freezing and subsequent thawing of sperm is a physically stressful process carried out during routine procedures in assisted reproduction techniques, which results in a highly variable and unpredictable reduction in the number of motile sperm cells. Subsequently, oxidative status can positively or negatively affect the motility, viability, and fertilizing capacity of thawed…