0000000000677149
AUTHOR
Yuping Zhao
Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis
Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC50 values of 5.0, 8.7, and 24.4 μM, respectively.
CCDC 1869183: Experimental Crystal Structure Determination
Related Article: Shuai Liu, Yuping Zhao, Christian Heering, Christoph Janiak, Werner E. G. Müller, Sergi Hervé Akoné, Zhen Liu, Peter Proksch|2019|J.Nat.Prod.|82|1055 |doi:10.1021/acs.jnatprod.8b00938