0000000000677154

AUTHOR

Jean-marc Regimbeau

showing 3 related works from this author

Perioperative FOLFOX 4 Versus FOLFOX 4 Plus Cetuximab Versus Immediate Surgery for High-Risk Stage II and III Colon Cancers: A Phase II Multicenter R…

2020

BACKGROUND Perioperative chemotherapy has proven valuable in several tumors, but not in colon cancer (CC). OBJECTIVE The aim of this study was to evaluate the efficacy and safety of perioperative chemotherapy in patients with locally advanced nonmetastatic CC. METHODS This is a French multicenter randomized phase II trial in patients with resectable high-risk T3, T4, and/or N2 CC on baseline computed tomography (CT) scan. Patients were randomized to receive either 6 months of adjuvant FOLFOX after colectomy (control) or perioperative FOLFOX for 4 cycles before surgery and 8 cycles after (FOLFOX peri-op). In RAS wild-type patients, a third arm testing perioperative FOLFOX-cetuximab was added…

AdultMalemedicine.medical_specialtyOrganoplatinum CompoundsColorectal cancermedicine.medical_treatmentPopulationLeucovorinCetuximab03 medical and health sciences0302 clinical medicineFOLFOXAntineoplastic Combined Chemotherapy ProtocolsMedicineHumanseducationColectomyColectomyAgedNeoplasm StagingTumor Regression Gradeeducation.field_of_studybusiness.industryPerioperativeMiddle Agedmedicine.diseaseInterim analysisdigestive system diseasesNeoadjuvant Therapy3. Good healthSurgeryTolerability030220 oncology & carcinogenesisColonic Neoplasms030211 gastroenterology & hepatologySurgeryFemaleFluorouracilFrancebusinessTomography X-Ray Computedmedicine.drugAnnals of surgery
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Does neoadjuvant FOLFOX chemotherapy improve the prognosis of high‐risk Stage II and III colon cancers? Three years' follow‐up results of the PRODIGE…

2021

International audience; Aim Neoadjuvant chemotherapy has proven valuable in locally advanced resectable colon cancer (CC) but its effect on oncological outcomes is uncertain. The aim of the present paper was to report 3-year oncological outcomes, representing the secondary endpoints of the PRODIGE 22 trial. Method PRODIGE 22 was a randomized multicentre phase II trial in high-risk T3, T4 and/or N2 CC patients on CT scan. Patients were randomized between 6 months of adjuvant FOLFOX (upfront surgery) or perioperative FOLFOX (four cycles before surgery and eight cycles after; FOLFOX perioperative). In wild-type RAS patients, a third arm testing perioperative FOLFOX-cetuximab was added. The pri…

Oncologymedicine.medical_specialtyOrganoplatinum CompoundsColorectal cancer[SDV]Life Sciences [q-bio]medicine.medical_treatmentPopulationLeucovorinsurvival03 medical and health sciences0302 clinical medicineFOLFOXInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineClinical endpointHumanseducationNeoplasm StagingColectomyeducation.field_of_studybusiness.industryHazard ratioGastroenterologyPerioperativecolectomyPrognosisInterim analysismedicine.diseaseNeoadjuvant Therapydigestive system diseasescolon cancerChemotherapy Adjuvant030220 oncology & carcinogenesisColonic Neoplasms030211 gastroenterology & hepatologyFluorouracilNeoplasm Recurrence Localbusinessneoadjuvant chemotherapyFollow-Up Studiesmedicine.drugColorectal Disease
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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

2018

Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments.

Male:Medicina Básica [Ciências Médicas]Computed tomography030230 surgery0302 clinical medicineAntibioticsDiagnosisAppendicitiProspective StudiesLaparoscopyProspective cohort studyTomographymedicine.diagnostic_testAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Surgery; Emergency MedicineAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment OutcomeMortality ratelcsh:Medical emergencies. Critical care. Intensive care. First aidApendicite3. Good healthX-Ray ComputedManagementHospitalizationTreatment Outcome030220 oncology & carcinogenesisCiências Médicas::Medicina BásicaAcute appendicitisAcute DiseaseEmergency MedicineFemaleAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment Outcome; Surgery; Emergency MedicineDiagnosiHumanResearch ArticleAdultmedicine.medical_specialtyLogistic Modellcsh:SurgeryNO03 medical and health sciencesmedicineAppendectomyHumansAcute appendicitisChi-Square Distributionbusiness.industryGeneral surgeryAntibioticAcute appendicitis; Antibiotics; Diagnosis; Management; Surgerylcsh:RD1-811lcsh:RC86-88.9Length of Staymedicine.diseaseAppendicitisAppendicitisProspective StudieLogistic ModelsObservational studyLaparoscopySurgeryAcute appendicitibusinessTomography X-Ray ComputedChi-squared distributionWorld Journal of Emergency Surgery
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