0000000000680243

AUTHOR

Pietro Leo

showing 9 related works from this author

A painless treatment for patients undergoing Milligan-Morgan haemorrhoidectomy.

2004

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Free perforation in Crohn's disease]

2004

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On-treatment serum albumin level can guide long-term treatment in patients with cirrhosis and uncomplicated ascites

2021

Background & Aims: The ANSWER study reported that long-term albumin administration in patients with cirrhosis and uncomplicated ascites improves survival. During treatment, serum albumin increased within a month and remained stable thereafter. In this post hoc analysis, we aimed to determine whether on-treatment serum albumin levels could guide therapy. Methods: Logistic regression was used to assess the association between baseline serum albumin and mortality, as well as to determine on-treatment factors associated with mortality and to predict the achievement of a given on-treatment serum albumin level. Survival was assessed by Kaplan-Meier estimates and second-order polynomial regres…

Male0301 basic medicineCirrhosisascites; complications; liver cirrhosis; serum albumin; survivalSerum albuminSurvival.Logistic regressionGastroenterologyBiomarkers PharmacologicalAscites; Cirrhosis; Complications; Serum albumin; Survivalascites0302 clinical medicineAscitesMedicinebiologyMiddle AgedIntention to Treat AnalysisTreatment OutcomeCirrhosisAsciteFemale030211 gastroenterology & hepatologyDrug Monitoringmedicine.symptommedicine.medical_specialtycomplicationsSettore MED/12 - GASTROENTEROLOGIAliver cirrhosisSerum albuminSerum Albumin Humansurvival03 medical and health sciencesSerum albumin levelPredictive Value of TestsInternal medicinePost-hoc analysisHumansIn patientBiological ProductsCirrhosiHepatologybusiness.industryAlbuminmedicine.diseaseLong-Term CareSurvival Analysis030104 developmental biologybiology.proteinbusinessComplication
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Etoposide, doxorubicin (Adriamycin) and cisplatin regimen in advanced gastric adenocarcinoma: experience with a lower dose schedule

1994

A phase II trial of etoposide (100 mg/m2) on days 4, 5, 6, doxorubicin (Adriamycin, 20 mg/m2) on days 1, 7, and cisplatin (30 mg/m2) on days 2, 8 (EAP) was carried out in order to reduce toxicity associated with a full-dose EAP regimen for advanced and/or metastatic gastric adenocarcinoma. Out of 21 evaluable patients, 2 (10%) had a complete response (CR), 7 (33%) had a partial response (PR), 4 (20%) showed no change and 8 progressed (38%). The mean duration of response (CR+PR) was 8.4+ months. Survival of the whole group was 7.5+ months. Treatment was quite well tolerated by most patients on an outpatient basis. Grade 3 vomiting and leukopenia were seen in 30% and 35% of cases respectively…

AdultMaleCancer Researchmedicine.medical_specialtyAdolescentmedicine.medical_treatmentAdenocarcinomaGastroenterologyDrug Administration ScheduleStomach NeoplasmsInternal medicineAntineoplastic Combined Chemotherapy ProtocolsmedicineHumansChemotherapyEtoposideAgedEtoposideCisplatinChemotherapyLeukopeniabusiness.industryStomachGeneral MedicineMiddle Agedmedicine.diseaseEAPSurgeryRegimenmedicine.anatomical_structureOncologyDoxorubicinVomitingAdenocarcinomaFemaleCisplatinmedicine.symptomGastric cancerbusinessmedicine.drugJournal of Cancer Research and Clinical Oncology
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Vantaggi degli ultrasuoni nel posizionamento di un agocannula nella vena giugulare interna (nuove note di tecnica)

2004

The authors analized the result of 175 central venous ca he- terization CVC. of internal jugular vein performed with the ultrasound guide (US) from January 1998 to October 2002. The average performing time was 45 minutes. 98.2% of success and 4% of complications (one pagal hypotension, one artery puncture, four catheter dislocation, one haeiuatoinai). The US guide CVC is a safe procedure with short performing time, low rate of failures and complications and high rate of success: it is helpful in all patients with vascular anatomical variations, with not visualized or Land marks and with coagulation disorders.

Central Venous catheterization CVC ultrasound guide
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Jejunal cystic lymphangioma in adult with rapid growth]

2004

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La perforazione in peritoneo libero nella malattia di Crohn

2004

Free perforation in abdominal cavity in patients with Crohn's disease is a rare entity as attested from the data reported in the literature. It is a very dangerous event and requires a surgical urgency management. The Authors reported two cases of free perforation, in patients with Crohn' disease, undergoing surgical operation in urgency. Analyzing pathogenesis, difficulty in diagnosis making and therapeutic choices, they underline that CT is very useful in the diagnosis, while resection of the perforated intestinal tract represent the best surgical treatment.

Crohn's disease free perforation peritonitis
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Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial

2018

Background Evidence is scarce on the efficacy of long-term human albumin (HA) administration in patients with decompensated cirrhosis. The human Albumin for the treatmeNt of aScites in patients With hEpatic ciRrhosis (ANSWER) study was designed to clarify this issue. Methods We did an investigator-initiated multicentre randomised, parallel, open-label, pragmatic trial in 33 academic and non-academic Italian hospitals. We randomly assigned patients with cirrhosis and uncomplicated ascites who were treated with anti-aldosteronic drugs (≥200 mg/day) and furosemide (≥25 mg/day) to receive either standard medical treatment (SMT) or SMT plus HA (40 g twice weekly for 2 weeks, and then 40 g weekly…

Liver CirrhosisMaleTime FactorsCirrhosisKaplan-Meier Estimatelaw.inventionascites0302 clinical medicineHepatorenal syndromeRandomized controlled trialFurosemidelawAscitesClinical endpointParacentesisDiureticsalbumin decompensated cirrhosiMineralocorticoid Receptor AntagonistsSettore MED/12 - GastroenterologiaMedicine (all)Hazard ratioGeneral MedicineMiddle AgedSurvival RateCirrhosis030220 oncology & carcinogenesisDrug Therapy CombinationFemale030211 gastroenterology & hepatologyQuality-Adjusted Life Yearsmedicine.symptomHyponatremiamedicine.medical_specialty03 medical and health sciencesAlbuminsInternal medicinemedicineHumansSurvival ratealbuminAgedbusiness.industrycirrhosis; albumin; ascitesmedicine.diseaseClinical trialalbumin cirrhosis ascites liver decompensationQuality of LifeHyperkalemiabusinessEsophagus Varices Portal Hypertension Varicosis
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Concomitant inflammatory pseudotumor of the liver and spleen.

2001

We report the case of a 53-year-old man with inflammatory pseudotumor (IPT) of the liver and spleen. This concomitant association has rarely been reported. The patient presented with a hypoechoic mass in the liver and a clinical picture of recurrent sepsis; hematochemical exams and imaging data were nonspecific. Antibiotic therapy improved the clinical course, but did not resolve it definitively. After 50 days of therapy, as the hepatic mass decreased a similar lesion appeared in the spleen. The final diagnosis was made on splenectomy and an intra-operative biopsy of the residual liver lesion. The diagnostic problems encountered in this very rare association of IPT of the liver and spleen w…

MaleHepatologyLiver DiseasesAngiographyMiddle AgedGranuloma Plasma CellImagingInflammatory pseudotumorTreatment OutcomeLiverSepsisSplenectomyHumansTomography X-Ray ComputedSpleenSplenic DiseasesUltrasonographyLiver
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