0000000000681681

AUTHOR

Christian Domingo

showing 4 related works from this author

The respiratory microbiome in bronchial mucosa and secretions from severe IgE-mediated asthma patients

2017

Altres ajuts: This work was supported by Fundació Catalana de Neumología (FUCAP) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES). CIBERES is an initiative of the Instituto de Salud Carlos III. The bronchial microbiome in chronic lung diseases presents an abnormal pattern, but its microbial composition and regional differences in severe asthma have not been sufficiently addressed. The aim of the study was to describe the bacterial community in bronchial mucosa and secretions of patients with severe chronic asthma chronically treated with corticosteroids in addition to usual care according to Global Initiative for Asthma. Bacterial community composition was…

DNA BacterialMale0301 basic medicineMicrobiology (medical)BiopsyMicrobial ConsortiaBronchimedicine.disease_causeImmunoglobulin EMicrobiology03 medical and health sciencesRNA Ribosomal 16SBronchoscopymedicinePrevotellaHumansMicrobiomeAsthmaMucous MembraneLungBacteriabiologyStreptococcusSputumFusobacteriaBiodiversitySequence Analysis DNAImmunoglobulin EMiddle Agedmedicine.diseasebiology.organism_classificationAsthmaCross-Sectional Studies030104 developmental biologymedicine.anatomical_structureImmunologybiology.proteinMetagenomeSputumFemaleMicrobiomemedicine.symptomBronchial aspirateResearch Article
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Care pathways for the selection of a biologic in severe asthma.

2017

Physicians need care pathways to select a biologic in type 2 severe asthma (omalizumab, mepolizumab, reslizumab) http://ow.ly/pygw30gB7Bv

Pulmonary and Respiratory Medicinemedicine.medical_specialtySevere asthmaMEDLINEmacromolecular substancesOmalizumab03 medical and health sciences0302 clinical medicineReslizumabmedicineHumans030212 general & internal medicineIntensive care medicineSelection (genetic algorithm)Randomized Controlled Trials as TopicAsthma therapyBiological Productsbusiness.industryAntibodies MonoclonalAsthma030228 respiratory systemPractice Guidelines as TopicCritical PathwaysbusinessMepolizumabmedicine.drugThe European respiratory journal
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dIvergEnt: How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies

2017

[EN] Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. The most common associated feature in the airways of patients with asthma is airway inflammation. In recent decades, efforts have been made to characterise the heterogeneous clinical nature of asthma. The interest in improving the definitions of asthma phenotypes and endotypes is growing, although these classifications do not always correlate with prognosis nor are always appropriate therapeutic approaches. Attempts have been made to identify the m…

AllergyDiseaseOmalizumabReviewOmalizumabImmunoglobulin Eimmunomodulation0302 clinical medicine030212 general & internal medicineanti-IgEAnti-Asthmatic Agentsbiological treatmentSpectroscopyBiología molecularbiologyAntibodies MonoclonalAllergic asthmaGeneral MedicineComputer Science Applicationsmedicine.symptommedicine.drugBioquímicaimmunological mechanismsmedicine.drug_classInflammationMonoclonal antibodyCatalysisInorganic Chemistry03 medical and health sciencesmedicineImmunologic FactorsAnimalsHumansfactores inmunitariosPhysical and Theoretical ChemistryMolecular BiologyAsthmaimmunoglobulin E (IgE)Inflammationbusiness.industryOrganic ChemistrybiomarkersMicrobiología médicaasthmaImmunoglobulin Emedicine.diseaseallergyrespiratory tract diseases030228 respiratory systemImmunologybiology.proteinbusiness
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Additional file 1: Table S1. of The respiratory microbiome in bronchial mucosa and secretions from severe IgE-mediated asthma patients

2017

Relative abundance (median, IQR) of all genera detected in BB and BA samples. (XLSX 32 kb)

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