0000000000682680
AUTHOR
Sara S. Nogueira
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems
Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020
Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery
Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-methylated glycine), which has previously shown potent stealth properties. Here, lipid nanoparticles (LNPs) for therapeutic application of messenger RNA were assembled using pSarcosinylated lipids as a tool for particle engineering. Using pSar lipids with different polymeric chain lengths and molar fractions enabled the control of the physicochemical characteristics of the LNPs, such as particle size, morphology, and internal structure. In combination with a suited ionizable lipid, LNPs were assembled, which displayed high RNA transfection potency with an improved safety profile after intravenous injection…
Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration
Molecular pharmaceutics 15(2), 642 - 651 (2018). doi:10.1021/acs.molpharmaceut.7b01022