0000000000682680

AUTHOR

Sara S. Nogueira

showing 4 related works from this author

Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

2020

Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034

0301 basic medicine570small angle scatteringNanoparticlecationic lipid02 engineering and technologyengineering.materialTransfectionArticleCell LineFatty Acids Monounsaturated03 medical and health sciencesMiceBiopolymersddc:570AnimalsHumansRNA MessengerParticle Sizelcsh:QH301-705.5chemistry.chemical_classificationMice Inbred BALB Ccancer immunotherapySmall-angle X-ray scatteringHeparinOptical ImagingCationic polymerizationGeneral MedicinePolymerTransfection021001 nanoscience & nanotechnologyvaccinationSmall-angle neutron scatteringLipidslipid-polymer hybrid nanoparticlesQuaternary Ammonium Compounds030104 developmental biologychemistrylcsh:Biology (General)cationic polymerBiophysicsengineeringNanoparticlesRNAFemalePolymer blendBiopolymer0210 nano-technologyCovid-19
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Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems

2019

Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020

570Static ElectricityBiophysicsBioengineering02 engineering and technologyGene deliveryBiomaterials03 medical and health scienceschemistry.chemical_compoundDrug Delivery SystemsX-Ray DiffractionDynamic light scatteringddc:570Scattering Small AngleHumansRNA MessengerParticle Size030304 developmental biology0303 health sciencesMessenger RNAHeparinSmall-angle X-ray scatteringDEAE-DextranBiological activityDendritic CellsTransfection021001 nanoscience & nanotechnologySmall-angle neutron scatteringDextranchemistryMechanics of MaterialsCeramics and CompositesBiophysics0210 nano-technology
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Polysarcosine-functionalized lipid nanoparticles for therapeutic mRNA delivery

2020

Polysarcosine (pSar) is a polypeptoid based on the endogenous amino acid sarcosine (N-methylated glycine), which has previously shown potent stealth properties. Here, lipid nanoparticles (LNPs) for therapeutic application of messenger RNA were assembled using pSarcosinylated lipids as a tool for particle engineering. Using pSar lipids with different polymeric chain lengths and molar fractions enabled the control of the physicochemical characteristics of the LNPs, such as particle size, morphology, and internal structure. In combination with a suited ionizable lipid, LNPs were assembled, which displayed high RNA transfection potency with an improved safety profile after intravenous injection…

chemistry.chemical_classificationMessenger RNAchemistry.chemical_compoundSarcosineBiochemistryChemistryGlycineDrug deliveryNanoparticleGeneral Materials ScienceEndogenyGene deliveryAmino acid
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Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration

2018

Molecular pharmaceutics 15(2), 642 - 651 (2018). doi:10.1021/acs.molpharmaceut.7b01022

0301 basic medicineModels MolecularDrug CompoundingKineticsLipid BilayersPharmaceutical Science610TransfectionCell LineMyoblasts03 medical and health sciencesMiceX-Ray DiffractionCationsDrug DiscoveryScattering Small AngleAnimalsRNA Messengerddc:610Lipid bilayerLuciferasesMessenger RNALiposomeDrug CarriersChemistryAqueous two-phase systemRNATransfection030104 developmental biologyDelayed-Action PreparationsLiposomesBiophysicsMolecular Medicinelipids (amino acids peptides and proteins)Drug carrier
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