Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Mesoscopic and Microscopic Investigation on Poly(vinyl alcohol) Hydrogels in the Presence of Sodium Decylsulfate
The structure of poly(vinyl alcohol) (PVA) hydrogels formed as a result of freeze/thaw treatments of aqueous solutions of the polymer (11 wt % PVA) in the freshly prepared state is analyzed through the combined use of small (SANS) and ultrasmall (USANS) angle neutron scattering techniques. The structure of these hydrogels may be described in terms of polymer rich regions, with dimensions of the order of 1-2 microm, dispersed in a water rich phase, forming two bicontinuous phases. The PVA chains in the polymer rich phase form a network where the cross-linking points are mainly crystalline aggregates of PVA having average dimensions of approximately 45 A. The structural organization of freeze…
Investigation of charge ratio variation in mRNA – DEAE-dextran polyplex delivery systems
Biomaterials 192, 612 - 620 (2019). doi:10.1016/j.biomaterials.2018.10.020