0000000000685248

AUTHOR

Barbara A. Cottrell

showing 2 related works from this author

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

2008

Proteolytic processing of the amyloid precursor protein by beta- and gamma-secretase generates the amyloid-beta (Abeta) peptides, which are principal drug targets in Alzheimer disease therapeutics. gamma-Secretase has imprecise cleavage specificity and generates the most abundant Abeta40 and Abeta42 species together with longer and shorter peptides such as Abeta38. Several mechanisms could explain the production of multiple Abeta peptides by gamma-secretase, including sequential processing of longer into shorter Abeta peptides. A novel class of gamma-secretase modulators (GSMs) that includes some non-steroidal anti-inflammatory drugs has been shown to selectively lower Abeta42 levels withou…

chemistry.chemical_classificationGel electrophoresisbiologyChinese hamster ovary cellMedizinWild typePeptideCell BiologyCleavage (embryo)biology.organism_classificationBiochemistrynervous system diseasesBiochemistrychemistrymental disordersAmyloid precursor proteinbiology.proteinCricetulusMolecular BiologyPeptide sequenceJournal of Biological Chemistry
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P4‐192: Mechanism of γ‐secretase cleavage: Evidence for independent generation of Aβ42 and Aβ38 peptide species

2008

chemistry.chemical_classificationCleavage factorEpidemiologyChemistryStereochemistryHealth PolicyPeptideCleavage (embryo)Psychiatry and Mental healthCellular and Molecular NeuroscienceDevelopmental NeuroscienceNeurology (clinical)γ secretaseGeriatrics and GerontologyAlzheimer's & Dementia
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