0000000000685611

AUTHOR

Nora L. Traulsen

showing 2 related works from this author

Evaluation of multivalency as an organization principle for the efficient synthesis of doubly and triply threaded amide rotaxanes

2014

Mono-, di- and trivalent pseudorotaxanes with tetralactam macrocycle hosts and axles containing diamide binding stations as the guests have been synthesised. Their threading behaviour was analyzed in detail by NMR experiments and isothermal titration calorimetry. An X-ray crystal structure of the monovalent pseudorotaxane confirms the binding motif. Double mutant cycle analysis provides the effective molarities and insight into the chelate cooperativity of multivalent binding. While the second binding event in a trivalent pseudorotaxane exhibits a slightly positive cooperativity, the third binding is nearly non-cooperative. Nevertheless, the enhanced binding affinities resulting from the mu…

RotaxaneTandemStereochemistryOrganic ChemistryCooperative bindingIsothermal titration calorimetryCooperativityNuclear magnetic resonance spectroscopyCrystal structure540Crystallographychemistry.chemical_compoundchemistryAmideta116Organic Chemistry Frontiers: an international journal of organic chemistry
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CCDC 938974: Experimental Crystal Structure Determination

2014

Related Article: Lena Kaufmann, Nora L. Traulsen, Andreas Springer, Hendrik V. Schröder, Toni Mäkelä, Kari Rissanen, Christoph A. Schalley|2014|Org.Chem.Front.|1|521|doi:10.1039/C4QO00077C

N-(2-(hexanoyl(methyl)amino)ethyl)-N-methylbenzamide 11'-iodo-5'17'23'35'38'40'43'45'-octamethyl-7'15'25'33'39'-pentaazadispiro[cyclohexane-12'-heptacyclo[32.2.2.2^36^.2^1619^.2^2124^.1^913^.1^2731^]hexatetracontane-20'1''-cyclohexane]-1'(36')3'5'9'(44')10'12'16'18'21'23'27'(39')28'30'34'37'40'42'45'-octadecaene-8'14'26'32'-tetroneSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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