Measurement of σ(e+e−→π+π−) from threshold to 0.85 GeV2 using initial state radiation with the KLOE detector

Measurement of σ(e+e−→π+π−) from threshold to 0.85 GeV2 using initial state radiation with the KLOE detector

Replacement Therapy for Minor Surgery and Invasive Procedures in Factor VII Deficiency: The STER Experience

Acquired Hemophilia A Associated with Venous Thrombosis and Very High Inhibitor Titer: A Challenging Scenario

Measurement of the branching ratio and search for a CP violating asymmetry in the η→π+π−e+e−(γ) decay at KLOE

Abstract We have studied the η → π + π − e + e − ( γ ) decay using about 1.7 fb − 1 collected by the KLOE experiment at the DAΦNE ϕ -factory. This corresponds to about 72 millions η mesons produced in ϕ radiative decays. We have measured the branching ratio, inclusive of radiative effects, with 4% accuracy: BR ( η → π + π − e + e − ( γ ) ) = ( 26.8 ± 0.9 Stat . ± 0.7 Syst . ) × 10 − 5 . We have obtained the first measurement of the CP-odd ππ – ee decay planes angular asymmetry, A ϕ = ( − 0.6 ± 2.5 Stat . ± 1.8 Syst . ) × 10 − 2 .

Search for heavy neutrinos at the NA48/2 and NA62 experiments at CERN

© The Authors, published by EDP Sciences. The NA48/2 experiment at CERN has collected large samples of charged kaons decaying into a pion and two muons for the search of heavy nuetrinos. In addition, its successor NA62 has set new limits on the rate of charged kaon decay into a heavy neutral lepton (HNL) and a lepton, with = e, µ, using the data collected in 2007 and 2015. New limits on heavy neutrinos from kaon decays into pions, muons and positrons are presented in this report.

Effective hemostasis during minor surgery in a case of hereditary combined deficiency of vitamin K-dependent clotting factors.

Combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated …

Observation of the rare η→e+e−e+e− decay with the KLOE experiment

Abstract We report the first observation of the rare η → e + e − e + e − ( γ ) decay based on 1.7 fb − 1 collected by the KLOE experiment at the DAΦNE ϕ-factory. The selection of the e + e − e + e − final state is fully inclusive of radiation. We have identified 362 ± 29 events resulting in a branching ratio of ( 2.4 ± 0.2 stat + bckg ± 0.1 syst ) × 10 − 5 .

Management of Kidney Transplantation in a Factor VII-Deficient Patient: Case Report

Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term …

Searches for lepton number violating $K^+$ decays

The NA62 experiment at CERN reports a search for the lepton number violating decays K+ -> pi(-)e(+)e(+) and K+ -> pi(-)mu(+)mu(+) using a data sample collected in 2017. No signals are observed, and upper limits on the branching fractions of these decays of 2.2 x 10(-10) and 4.2 x 10(-11) are obtained, respectively, at 90% confidence level. These upper limits improve on previously reported measurements by factors of 3 and 2, respectively.

Search for heavy neutrinos in K + → μ + ν μ decays

The NA62 experiment recorded a large sample of K+→μ+νμ decays in 2007. A peak search has been performed in the reconstructed missing mass spectrum. In the absence of a signal, limits in the range 2×10−6 to 10−5 have been set on the squared mixing matrix element |Uμ4|2 between muon and heavy neutrino states, for heavy neutrino masses in the range 300–375 MeV/ c2 . The result extends the range of masses for which upper limits have been set on the value of |Uμ4|2 in previous production search experiments.

Replacement therapy for bleeding episodes in factor VII deficiency: A prospective evaluation

Patients with inherited factor VII (FVII) deficiency display different clinical phenotypes requiring ad hoc management. This study evaluated treatments for spontaneous and traumatic bleeding using data from the Seven Treatment Evaluation Registry (STER). One-hundred one bleeds were analysed in 75 patients (41 females; FVII coagulant activity <1-20%). Bleeds were grouped as haemarthroses (n=30), muscle/subcutaneous haematomas (n=16), epistaxis (n=12), gum bleeding (n=13), menorrhagia (n=16), central nervous system (CNS; n=9), gastrointestinal (GI; n=2) and other (n=3). Of 93 evaluable episodes, 76 were treated with recombinant, activated FVII (rFVIIa), eight with fresh frozen plasma (FFP), s…

Search for heavy neutral lepton production in K+ decays to positrons

A search for heavy neutral lepton ($N$) production in $K^+\to e^+N$ decays using the data sample collected by the NA62 experiment at CERN in 2017--2018 is reported. Upper limits of the extended neutrino mixing matrix element $|U_{e4}|^2$ are established at the level of $10^{-9}$ over most of the accessible heavy neutral lepton mass range 144--462 MeV/$c^2$, with the assumption that the lifetime exceeds 50 ns. These limits improve significantly upon those of previous production and decay searches. The $|U_{e4}|^2$ range favoured by Big Bang Nucleosynthesis is excluded up to a mass of about 340 MeV/$c^2$.

Prophylaxis in congenital factor VII deficiency: indications, efficacy and safety. Results from the Seven Treatment Evaluation Registry (STER)

WOS: 000319897700018

Search for K+→ π+νν¯ at NA62

Flavour physics is one of the most powerful fields for the search of new physics beyond the Standard Model. The kaon sector with the rare decay K+ → π+νν̅ provides one of the cleanest and most promising channels. NA62, a fixed target experiment at the CERN SPS, aims to measure BR (K+ → π+νν̅) with 10% precision to test the Standard Model validity up to an energy scale of hundreds of TeV. NA62 had dedicated data taking for the K+ → π+νν̅ measurement in 2016 and 2017 and will continue in 2018. Here preliminary results on a fraction of 2016 dataset are presented. The analysis of the complete 2016 data sample is expected to achieve the SM sensitivity.

The ISTH bleeding assessment tool as predictor of bleeding events in inherited platelet disorders: Communication from the ISTH SSC Subcommittee on Platelet Physiology.

Background: The ISTH Bleeding Assessment Tool (ISTH-BAT) has been validated for clinical screening of suspected von Willebrand disease (VWD) and for bleeding prediction. Recently it has been validated for subjects with inherited platelet disorders (IPD) (BAT-VAL study). Objectives: To determine whether the ISTH-BAT bleeding score (BS) predicts subsequent bleeding events requiring treatment in IPD patients. Methods: Patients with IPD, type 1 VWD (VWD-1) and age- and sex-matched healthy controls enrolled in the BAT-VAL study were prospectively followed-up for 2 years and bleeding episodes requiring treatment were recorded. Results: Of the 1098 subjects initially enrolled, 955 were followed-up…

NA48/62 latest results

The NA62 experiment at the CERN SPS recorded in 2007 a large sample of K+ ? µ+?µ decays. A peak search in the missing mass spectrum of this decay is performed. In the absence of observed signal, the limits obtained on B(K+ ? µ+?h) and on the mixing matrix element |Uµ 4| are reported. The upgraded NA62 experiment started data taking in 2015. About 5×1011K+ decays have been recorded so far to measure the branching ratio of the K+ ? ?+?? decay. Preliminary results from the K+ ? ?+?? analysis based on about 5% of the 2016 statistics are reported.

Hereditary combined deficiency of the vitamin K-dependent clotting factors

Abstract Hereditary combined vitamin K-dependent clotting factors deficiency (VKCFD) is a rare congenital bleeding disorder resulting from variably decreased levels of coagulation factors II, VII, IX and X as well as natural anticoagulants protein C, protein S and protein Z. The spectrum of bleeding symptoms ranges from mild to severe with onset in the neonatal period in severe cases. The bleeding symptoms are often life-threatening, occur both spontaneously and in a surgical setting, and usually involve the skin and mucosae. A range of non-haemostatic symptoms are often present, including developmental and skeletal anomalies. VKCFD is an autosomal recessive disorder caused by mutations in …

The impact of deep vein thrombosis in critically ill patients: a meta-analysis of major clinical outcomes

Background. Critically ill patients appear to be at high risk of developing deep vein thrombosis (DVT) and pulmonary embolism during their stay in the intensive care unit (ICU). However, little is known about the clinical course of venous thromboembolism in the ICU setting. We therefore evaluated, through a systematic review of the literature, the available data on the impact of a diagnosis of DVT on hospital and ICU stay, duration of mechanical ventilation and mortality in critically ill patients. We also tried to determine whether currently adopted prophylactic measures need to be revised and improved in the ICU setting. Materials and methods. MEDLINE and EMBASE databases were searched up…

Search for the decay ϕ→K0K¯0γ with the KLOE experiment

Abstract We have searched for the decay ϕ → K 0 K ¯ 0 γ , by detecting K S pairs plus a photon and with the K S -mesons decaying to π + π − , in a sample of about 1.5 × 10 9 ϕ-decays collected by the KLOE experiment at DAΦNE. The reaction proceeds through the intermediate states f 0 ( 980 ) γ , a 0 ( 980 ) γ . We find five events with 3.2 events expected from background processes. We obtain the upper limit: BR ( ϕ → K 0 K ¯ 0 γ ) 1.9 × 10 − 8 at 90% CL.

Search for heavy neutral lepton production in K+ decays

A search for heavy neutral lepton production in $K^+$ decays using a data sample collected with a minimum bias trigger by the NA62 experiment at CERN in 2015 is reported. Upper limits at the $10^{-7}$ to $10^{-6}$ level are established on the elements of the extended neutrino mixing matrix $|U_{\ell 4}|^2$ ($\ell=e,\mu$) for heavy neutral lepton mass in the range $170-448~{\rm MeV}/c^2$. This improves on the results from previous production searches in $K^+$ decays, setting more stringent limits and extending the mass range.

Precision measurement of the K S meson lifetime with the KLOE detector

Using a large sample of pure, slow, short lived K0 mesons collected with KLOE detector at DaFne, we have measured the KS lifetime. From a fit to the proper time distribution we find tau = (89.562 +- 0.029_stat +- 0.043_syst) ps. This is the most precise measurement today in good agreement with the world average derived from previous measurements. We observe no dependence of the lifetime on the direction of the Ks.

Phenotypic APC resistance as a marker of hypercoagulability in primitive cerebral lymphoma

Thrombosis is the most frequent complication and the second cause of death in patients with malignant disease. Primary central nervous system non-Hodgkin's lymphoma represents a rare pathology. Resistance to APC is usually linked to a factor V (FV) gene mutation changing an Arg 506 to a Gln in the APC cleavage site.In our study, we aimed at investigating the presence of activated protein C resistance (APC-r) and other markers of hypercoagulability in 25 selected patients with a diagnosis of primitive cerebral lymphoma who had suffered from an ischemic episode of TIA and/or stroke.25 selected patients with a diagnosis of primitive cerebral lymphoma and 50 healthy subjects acted as control gr…

VITAMIN K-INDUCED MODIFICATION OF COAGULATION PHENOTYPE IN VKORC1 HOMOZYGOUS DEFICIENCY

Summary.  Background: Combined vitamin K-dependent clotting factor (VKCF) deficiency type 2 (VKCFD2) is a rare bleeding disorder caused by mutated vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) gene. Methods and results: An Italian patient with moderate to severe bleeding tendency was genotyped, and found to be homozygous for the unique VKORC1 mutation (Arg98Trp) so far detected in VKCFD2. The activity levels of VKCFs were differentially reduced, and inversely related to the previously estimated affinity of procoagulant factor propeptides for the γ-carboxylase. The normal (factor IX) or reduced antigen levels (other VKCFs) produced a gradient in specific activities. Vitamin K su…

Search for Lepton Number and Flavor Violation in K+ and π0 Decays

Searches for the lepton number violating $K^{+} \rightarrow \pi^{-} \mu^{+} e^{+}$ decay and the lepton flavour violating $K^{+} \rightarrow \pi^{+} \mu^{-} e^{+}$ and $\pi^{0} \rightarrow \mu^{-} e^{+}$ decays are reported using data collected by the NA62 experiment at CERN in $2017$-$2018$. No evidence for these decays is found and upper limits of the branching ratios are obtained at 90% confidence level: $\mathcal{B}(K^{+}\rightarrow\pi^{-}\mu^{+}e^{+})<4.2\times 10^{-11}$, $\mathcal{B}(K^{+}\rightarrow\pi^{+}\mu^{-}e^{+})<6.6\times10^{-11}$ and $\mathcal{B}(\pi^{0}\rightarrow\mu^{-}e^{+})<3.2\times 10^{-10}$. These results improve by one order of magnitude over previous results for thes…

Study of the K±→π±γγ decay by the NA62 experiment

Abstract A study of the dynamics of the rare decay K ± → π ± γ γ has been performed on a sample of 232 decay candidates, with an estimated background of 17.4 ± 1.1 events, collected by the NA62 experiment at CERN in 2007. The results are combined with those from a measurement conducted by the NA48/2 Collaboration at CERN. The combined model-independent branching ratio in the kinematic range z = ( m γ γ / m K ) 2 > 0.2 is B MI ( z > 0.2 ) = ( 0.965 ± 0.063 ) × 10 − 6 , and the combined branching ratio in the full kinematic range assuming a Chiral Perturbation Theory description is B ( K π γ γ ) = ( 1.003 ± 0.056 ) × 10 − 6 . A detailed comparison of the results with the previous measurements…

"Long term anticoagulant treatment management in patients with portal vein thrombosis at high bleeding risk"

anticoagulant treatment.

Test of lepton flavour universality in K+→ℓ+ν decays

Abstract A precision test of lepton flavour universality has been performed by measuring the ratio R K of kaon leptonic decay rates K + → e + ν and K + → μ + ν in a sample of 59 813 reconstructed K + → e + ν candidates with ( 8.71 ± 0.24 ) % background contamination. The result R K = ( 2.487 ± 0.013 ) × 10 − 5 is in agreement with the Standard Model expectation.

Sorafenib as a feasible therapeutic option in haemophiliacs with hepatocellular carcinoma

hepatocellular carcinoma, haemophilia, treatment

Precision measurement of the ratio of the charged kaon leptonic decay rates

A precision measurement of the ratio RK of the rates of kaon leptonic decays K+- --&gt; e nu and K+- --&gt; mu nu with the full data sample collected by the NA62 experiment at CERN in 2007-2008 is reported. The result, obtained by analysing ~150000 reconstructed K+- --&gt; e nu candidates with 11% background contamination, is RK = (2.488+-0.010)*10^{-5}, in agreement with the Standard Model expectation.

Recombinant, activated factor VII for surgery in factor VII deficiency: a prospective evaluation - the surgical STER

Excessive bleeding represents a major complication of surgical interventions and its control is especially relevant in patients with Congenital Bleeding Disorders (CBD). In factor VII (FVII) deficiency, scanty data on surgery is available to guide treatment strategies. The STER (Seven Treatment Evaluation Registry) is a multi-centre, prospective, observational, web-based study protocol providing the frame for a structured and detailed data collection. Inhibitor occurrence was checked in a centralized fashion. Forty-one surgical operations (24 'major' and 17 'minor') were performed in 34 subjects with a carefully characterized FVII deficiency under the coverage of recombinant activated Facto…

Measurement of the η→3π0 slope parameter α with the KLOE detector

Abstract We present a measurement of the slope parameter α for the η → 3 π 0 decay, with the KLOE experiment at the DAΦNE ϕ -factory, based on a background free sample of ∼17 million η mesons produced in ϕ radiative decays. By fitting the event density in the Dalitz plot we determine α = − 0.0301 ± 0.0035 stat − 0.0035 + 0.0022 syst . The result is in agreement with recent measurements from hadro- and photo-production experiments.

Search for neutral MSSM Higgs bosons at LEP

The four LEP collaborations, ALEPH, DELPHI, L3 and OPAL, have searched for the neutral Higgs bosons which are predicted by the Minimal Supersymmetric Standard Model (MSSM). The data of the four collaborations are statistically combined and examined for their consistency with the background hypothesis and with a possible Higgs boson signal. The combined LEP data show no significant excess of events which would indicate the production of Higgs bosons. The search results are used to set upper bounds on the cross-sections of various Higgs-like event topologies. The results are interpreted within the MSSM in a number of "benchmark" models, including CP-conserving and CP-violating scenarios. Thes…

Hemophilia Clinical Consults: Epidemiology, Clinical Course, and Management of Acquired Hemophilia A