0000000000687589
AUTHOR
C. Winkler
INTEGRAL monitoring of the Black Hole candidate 1E 1740.7-2942
The brightest persistent Galactic black hole candidate close to the Galactic Centre, 1E 1740.7-2942, has long been observed with INTEGRAL. In this paper, we report on the long-term hard X-ray monitoring obtained during the first year of observations as part of the Galactic Centre Deep Exposure. We discuss the temporal and spectral behaviours in different energy bands up to 250 keV, as well as the hardness-flux correlations.
Radiolabeled DNase, a potential indicator for noninvasive detection of tissue damage
Pancreatic DNase I was labeled with 131I or fluorescamine and injected IV into NMRI mice bearing a sarcoma 180. Of the injected tracer, 1.5%-2% was found to accumulate per g tumor. In sections of tumor tissue DNase was localized in damaged cells in solid and necrotic tumor regions. This binding is most probably due to specific interaction of DNase with actin, an ubiquitous cytoskeletal protein. Two-component blood clearance with a rapid first component (two-thirds of applied radioactivity) was observed. The labeled tumor could easily be visualized by gamma camera imaging. The findings suggest DNase to be a potent radiopharmaceutical for imaging damaged tissue, occurring in malignant tumors …