0000000000699237
AUTHOR
M. Rodier
Exogenous t-PA Administration Increases Hippocampal Mature BDNF Levels. Plasmin- or NMDA-Dependent Mechanism?
International audience; Brain-derived neurotrophic factor (BDNF) through TrkB activation is central for brain functioning. Since the demonstration that plasmin is able to process pro-BDNF to mature BDNF and that these two forms have opposite effects on neuronal survival and plasticity, a particular attention has been paid to the link between tissue plasminogen activator (tPA)/plasmin system and BDNF metabolism. However, t-PA via its action on different N-methyl-D-aspartate (NMDA) receptor subunits is also considered as a neuromodulator of glutamatergic transmission. In this context, the aim of our study was to investigate the effect of recombinant (r)t-PA administration on brain BDNF metabo…
Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?
International audience; Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, several rehabilitation therapies have been undertaken and many experimental studies have reported that brain-derived neurotrophic factor (BDNF) is central to many facets of neuroplastic processes. However, although BDNF role in brain plasticity is well characterized through strategies that manipulate its content, the involvement of this neurotrophin in spontan…
''Role of rt-pa on bdnf metabolism in stroke''
Rodier, M. | Mossiat, C. | Marie, C. | Garnier, P.; International audience
''Ipsilateral vs. contralateral post-stroke neuroplastic changes: involvement of BDNF?''
Madinier, A. | Rodier, M. | Quirie, A. | Bertrand, N. | Mossiat, C. | Marie, C. | Garnier, P.; International audience