0000000000701716

AUTHOR

Sandra Atienzar-aroca

showing 2 related works from this author

Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation

2018

Autophagy and exosome secretion play important roles in a variety of physiological and disease states, including the development of age‐related macular degeneration. Previous studies have demonstrated that these cellular mechanisms share common pathways of activation. Low oxidative damage in ARPE‐19 cells, alters both autophagy and exosome biogenesis. Moreover, oxidative stress modifies the protein and genetic cargo of exosomes, possibly affecting the fate of surrounding cells. In order to understand the connection between these two mechanisms and their impact on angiogenesis, stressed ARPE‐19 cells were treated with a siRNA‐targeting Atg7, a key protein for the formation of autophagosomes.…

0301 basic medicineautophagyretinaAngiogenesisretinal pigment epitheliumNeovascularization PhysiologicexosomesExosomeMacular Degeneration03 medical and health sciencesangiogenesismedicineHumansGene silencingoxidative stressSecretionCells CulturedTube formationRetinal pigment epitheliumBiología molecularChemistryAutophagyAutophagosomesOriginal ArticlesCell BiologyVascular Endothelial Growth Factor Receptor-2MicrovesiclesCell biologyOxidative Stress030104 developmental biologymedicine.anatomical_structureVEGFR2siRNAMolecular MedicineOriginal Article
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Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells.

2015

10 páginas, 5 figuras

0301 basic medicineVascular Endothelial Growth Factor AAngiogenesisretinal pigment epitheliumNeovascularization PhysiologicexosomesBiologyExosomesExosomeCell Line03 medical and health sciencesangiogenesismedicineHuman Umbilical Vein Endothelial CellsHumansRNA MessengerRetinal pigment epitheliumVEGF receptorsTube formationRetinal pigment epitheliumEthanolCell BiologyOriginal ArticlesMicrovesicleseye diseasesCell biologyEndothelial stem cellVascular endothelial growth factor AOxidative Stress030104 developmental biologymedicine.anatomical_structureReceptors Vascular Endothelial Growth FactorOxidative stressCell cultureMolecular MedicineOriginal ArticleAngiogenesissense organsJournal of cellular and molecular medicine
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