0000000000702116

AUTHOR

Anna Maria Maccioni

showing 4 related works from this author

Composition influence on pulmonary delivery of rifampicin liposomes.

2012

The effects of lipid concentration and composition on the physicochemical properties, aerosol performance and in vitro toxicity activity of several rifampicin-loaded liposomes were investigated. To this purpose, six liposome formulations containing different amounts of soy phosphatidylcholine and hydrogenated soy phosphatidylcholine, with and without cholesterol and oleic acid, were prepared and fully characterized. Uni- or oligo-lamellar, small (~100 nm), negatively charged (~60 mV) vesicles were obtained. Lipid composition affected aerosol delivery features of liposomal rifampicin; in particular, the highest phospholipid concentration led to a better packing of the vesic…

liposomesaerosolPhospholipidpulmonary deliveryPharmaceutical Sciencelcsh:RS1-441liposomes; rifampicin; cholesterol; oleic acid; rheology; pulmonary delivery; aerosol; cell viability; cellular uptakerifampicinArticlelcsh:Pharmacy and materia medicachemistry.chemical_compoundPhosphatidylcholineMedicinecell viabilityLiposomeChromatographyCholesterolbusiness.industryVesiclecholesterolcellular uptakeIn vitroOleic acidchemistryBiochemistryoleic acidToxicitylipids (amino acids peptides and proteins)rheologybusinessPharmaceutics
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Glycerosomes: Use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration.

2016

In this work, diclofenac was encapsulated, as sodium salt, in glycerosomes containing 10, 20 or 30% of glycerol in the water phase with the aim to ameliorate its topical efficacy. Taking into account previous findings, glycerosome formulation was modified, in terms of economic suitability, using a cheap and commercially available mixture of hydrogenated soy phosphatidylcholine (P90H). P90H glycerosomes were spherical and multilamellar; photon correlation spectroscopy showed that obtained vesicles were ∼131nm, slightly larger and more polydispersed than those made with dipalmitoylphosphatidylcholine (DPPC) but, surprisingly, they were able to ameliorate the local delivery of diclofenac, whic…

3003GlycerolKeratinocytesDiclofenacSwineSkin Absorptionpig skinPharmaceutical Science02 engineering and technology030226 pharmacology & pharmacyDSC03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDiclofenacDrug Delivery SystemsOrgan Culture TechniquesDynamic light scatteringPhosphatidylcholinemedicineGlycerolAnimalsHumansCells CulturedChromatographyhydrogenated phospholipid vesiclesChemistryVesicle(trans)dermal drug delivery; DSC; hydrogenated phospholipid vesicles; keratinocytes; pig skin; rheology; 3003021001 nanoscience & nanotechnology(trans)dermal drug deliveryDipalmitoylphosphatidylcholineSkin penetrationDrug deliveryPhosphatidylcholinesrheologyHydrogenationSoybeans0210 nano-technologymedicine.drugInternational journal of pharmaceutics
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Glycerosomes:investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances

2017

Glycerosomes were formulated using 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC), diclofenac sodium salt and 10, 20 or 30% glycerol in the water phase, while corresponding liposomes were prepared with the same amount of DMPC and diclofenac, without glycerol. The aim of the present work was to evaluate the effect of the used phospholipid on vesicle features and ability to favour diclofenac skin deposition by comparing these results with those found in previous works performed using hydrogenated soy phosphatidylcholine (P90H) and dipalmitoylphosphatidylcholine (DPPC). Liposomes and glycerosomes were multilamellar, liposomes being smaller (72±6nm). Interactions among glycerol, phospho…

liposomes3003skindimyristoylphosphatidylcholinePhospholipidPharmaceutical Science02 engineering and technologyrehological studies010402 general chemistry01 natural sciencesDSCchemistry.chemical_compoundglycerosomesdrug delivery systemsPhosphatidylcholineGlycerolskin deliveryDSC; glycerosomes; rehological studies; SAXS; skin delivery; animals; diclofenac; dimyristoylphosphatidylcholine; liposomes; skin; swine; drug delivery systems; skin absorption; 3003LiposomeChromatographyBilayerVesicletechnology industry and agricultureswineDiclofenac SodiumSAXS021001 nanoscience & nanotechnologyskin absorption0104 chemical sciencesanimalsdiclofenacchemistryDipalmitoylphosphatidylcholinelipids (amino acids peptides and proteins)0210 nano-technology
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Development of novel diolein–niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment

2014

Abstract This work describes innovative niosomes, composed of diolein alone or in association with the hydrophilic penetration enhancer Labrasol ® , as carriers for cutaneous drug delivery. The model drug was tretinoin and conventional, and Labrasol ® containing liposomes was used as controls to evaluate the influence of vesicle composition and the role of Labrasol ® on vesicle physico-chemical properties and performance as skin delivery system. Vesicles, prepared by the thin film hydration technique, were characterized in terms of size distribution, morphology, zeta potential, structure, incorporation efficiency, and rheological properties. The influence of carrier composition on tretinoin…

KeratinocytesSurface PropertiesDrug CompoundingSkin AbsorptionPharmaceutical ScienceTretinoinHuman skinNanotechnologyIn Vitro TechniquesAdministration CutaneousGlyceridesDiglyceridesX-Ray DiffractionStratum corneummedicineZeta potentialHumansNiosomeParticle SizeCells CulturedSkinDrug CarriersLiposomeMicroscopy ConfocalChemistryBilayerVesicleEndocytosismedicine.anatomical_structureLiposomesDrug deliveryBiophysicsRheologyInternational Journal of Pharmaceutics
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