0000000000702437

AUTHOR

Giorgia Vajana

showing 2 related works from this author

Familial essential thrombocythemia: 6 cases from a mono‐institutional series

2022

Rarely essential thrombocythemia (ET) is diagnosed in more than one person within a family. Familial myeloproliferative neoplasms are underdiagnosed. In this report, we describe 6 couples of familial ET, evaluating the heterogeneity of the mutational state and the clinical presentation.

essential thrombocythemia familial myeloproliferative neoplasmsGeneral MedicineClinical Case Reports
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Triple-Negativity Identifies a Subgroup of Patients with Better Overall Survival in Essential Thrombocythemia

2022

Essential thrombocythemia, as defined by the WHO in 2016, is a Philadelphia-negative chronic myeloproliferative neoplasm showing a better prognosis than polycythemia vera and myelofibrosis. In a variable percentage, patients with essential thrombocythemia show none of the known driver-gene mutations that may occur on JAK2, CALR, and MPL genes. Such patients are classified as triple-negative and their clinical features and prognosis have not been described with precision yet. In this study, we evaluated some of the characteristics of this population by comparing them with those of patients with driver-gene mutated ET. Data from 266 consecutive essential thrombocythemia patients were analysed…

essential thrombocythemia survival triple-negative triple-negativityHematology
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