0000000000704421

AUTHOR

François Lokiec

showing 2 related works from this author

Acute and delayed toxicity of gemcitabine administered during isolated lung perfusion: a preclinical dose-escalation study in pigs.

2014

BACKGROUND: Colorectal cancer is the third most commonly diagnosed cancer worldwide, with up to 25% of patients presenting with metastases at the time of diagnosis. Despite pulmonary metastasectomy many patients go on to develop pulmonary recurrence, which might be linked to the presence of lung micrometastases. In this setting, the adjuvant administration of high-dose chemotherapy by isolated lung perfusion (ILP) has shown encouraging results. However, the tolerance to and efficacy of modern gemcitabine (GEM)-based chemotherapy regimens during adjuvant ILP remain unknown. We conducted a dose-escalating preclinical study to evaluate the immediate and delayed toxicity of GEM in a pig model t…

Pulmonary and Respiratory Medicinemedicine.medical_specialtyAntimetabolites AntineoplasticLung Neoplasmsendocrine system diseasesPulmonary toxicityIsolated lung perfusionmedicine.medical_treatmentAcute Lung InjurySus scrofaDrug Evaluation PreclinicalAnesthesia GeneralGastroenterologyDeoxycytidineInternal medicinemedicineAnimalsLungChemotherapyLungDose-Response Relationship Drugbusiness.industryGeneral MedicineChemotherapy regimenGemcitabineGemcitabineDisease Models Animalmedicine.anatomical_structureAnesthesiaChemotherapy Cancer Regional PerfusionToxicityAcute DiseaseSurgeryFemaleMetastasectomyCardiology and Cardiovascular Medicinebusinessmedicine.drugEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
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Isolated Lung Perfusion as an Adjuvant Treatment of Colorectal Cancer Lung Metastases: A Preclinical Study in a Pig Model

2012

BackgroundThe lung is a frequent site of colorectal cancer (CRC) metastases. After surgical resection, lung metastases recurrences have been related to the presence of micrometastases, potentially accessible to a high dose chemotherapy administered via adjuvant isolated lung perfusion (ILP). We sought to determine in vitro the most efficient drug when administered to CRC cell lines during a short exposure and in vivo its immediate and delayed tolerance when administered via ILP.MethodsFirst, efficacy of various cytotoxic molecules against a panel of human CRC cell lines was tested in vitro using cytotoxic assay after a 30-minute exposure. Then, early (operative) and delayed (1 month) tolera…

OncologyCardiothoracic SurgeryPathologyLung NeoplasmsSwineColorectal cancerIsolated lung perfusionmedicine.medical_treatmentCancer TreatmentCardiovascularDeoxycytidineMetastasischemistry.chemical_compoundDrug DistributionMultidisciplinaryQRThoracic SurgeryPerfusionTreatment OutcomeSurgical Oncologymedicine.anatomical_structureOncologyChemotherapy AdjuvantMedicineDeoxycytidineColorectal NeoplasmsAdjuvantResearch ArticleDrugs and Devicesmedicine.medical_specialtyScienceAntineoplastic AgentsIn vivoCell Line TumorInternal medicinemedicineAnimalsHumansPulmonary Vascular DiseasesPharmacokineticsAnalysis of VarianceChemotherapyLungDose-Response Relationship Drugbusiness.industryHemodynamicsChemotherapy and Drug Treatmentmedicine.diseaseGemcitabineDrug LiberationchemistryVasoconstrictionSurgerybusinessPLoS ONE
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