Author: Sophie Mouillet-richard

0000000000704828

AUTHOR

Sophie Mouillet-richard

0000-0002-8950-1949

showing 1 related works from this author

Intratumor CMS Heterogeneity Impacts Patient Prognosis in Localized Colon Cancer

2021

Abstract Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is the new frontier for refining prognostication and understanding treatment resistance. This study aims at deciphering the transcriptomic ITH of colon cancer and understanding its potential prognostic implications. Experimental Design: We deconvoluted the transcriptomic profiles of 1,779 tumors from the PETACC8 trial and 155 colon cancer cell lines as weighted sums of the four CMSs, using the Weighted In Silico Pathology (WISP) algorithm. We assigned to each tumor and cell line a combination of up to three …

OncologyMaleCancer Researchmedicine.medical_specialtyMultivariate analysisColorectal cancer[SDV]Life Sciences [q-bio]CellContext (language use)[SDV.CAN]Life Sciences [q-bio]/CancerBiologyTranscriptome[SDV.CAN] Life Sciences [q-bio]/CancerInternal medicineCell Line TumormedicineTumor MicroenvironmentHumansTreatment resistancehealth care economics and organizationsAgedbusiness.industryGene Expression ProfilingHazard ratiomedicine.diseasePrognosisSurvival Rate[SDV] Life Sciences [q-bio]medicine.anatomical_structureOncologyColonic NeoplasmsFemalePersonalized medicinebusiness

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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  - PE2_10Atomic, molecular physics
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  - PE2_14Lasers, ultra-short lasers and laser physics
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- PE1Mathematics
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LSLife Sciences
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SHSocial Sciences and Humanities
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