0000000000709046

AUTHOR

Leo Lahti

showing 4 related works from this author

Prebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats

2020

Understanding the importance of the gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat content associated with low abundance of Faecalibacterium prausnitzii in humans and, further, the administration of F. prausnitzii prevented NAFLD in mice. Here, we aimed at targeting F. prausnitzii by prebiotic xylo-oligosaccharides (XOS) to treat NAFLD. First, the effect of XOS on F. prausnitzii growth was assessed in vitro. Then, XOS was supplemented or not with high (HFD, 60% of energy from fat) or low (LFD) fat diet for 12 weeks in Wistar rats (n = 10/group). XOS increased F. prausnitzii growth, having onl…

MalesuolistomikrobistoPROGRESSIONBIFIDOBACTERIASTEATOHEPATITISNon-alcoholic Fatty Liver DiseaseCecumDiet Fat-RestrictedaineenvaihduntaFatty Acidsrasvamaksafood and beveragesmitochondriaLiverprebioticBody CompositionBIOPSIESFemaleOxidation-Reductionlcsh:Nutrition. Foods and food supplymitokondriotGlucuronateslcsh:TX341-641Diet High-Fatdigestive systemArticleDYSBIOSISprebiootitINFLAMMATIONLIVER-DISEASEINTESTINAL MICROBIOTAoligosaccharidesoligosakkariditAnimalsRats WistarTriglyceridesfatty livergut microbiotaFaecalibacterium prausnitziinutritional and metabolic diseasesLipid MetabolismGastrointestinal MicrobiomeRatsFAECALIBACTERIUM-PRAUSNITZIIGlucosePrebiotics416 Food Scienceaineenvaihduntatuotteet3111 BiomedicineEnergy IntakeEnergy MetabolismmetabolismNutrients
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Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Mic…

2021

We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a use…

MaleDOWN-REGULATIONsuolistomikrobistoHealth Toxicology and Mutagenesismedicine.medical_treatmentOligosaccharidesPROTEINAdipose tissuelcsh:MedicineGut florabiclusteringGLUCOSE0302 clinical medicineAMINO-ACIDSxylo-oligosaccharidesaineenvaihduntametabolites2. Zero hungerINSULIN-RESISTANCE0303 health sciencesmicroRNAhigh fat diet1184 Genetics developmental biology physiology3142 Public health care science environmental and occupational health3. Good healthCHAIN FATTY-ACIDSAdipose TissueLiverB-CELLSOBESITY1181 Ecology evolutionary biology030211 gastroenterology & hepatologymedicine.symptommedicine.medical_specialtyInflammationBiologyDiet High-FatArticle03 medical and health sciencesMetabolomicsprebiootitLIVER-DISEASEInternal medicineMetabolomemedicineAnimalsbiochemistryRats Wistar1172 Environmental sciences030304 developmental biologyInflammationgut microbiotaPrebioticlcsh:RPublic Health Environmental and Occupational Healthnon-alcoholic fatty liver diseaseACETYL-COA CARBOXYLASEksylo-oligosakkariditbiology.organism_classificationmedicine.diseaserotta (laji)Fatty LiverratsInsulin receptorEndocrinologyei-alkoholiperäinen rasvamaksasairaus3121 General medicine internal medicine and other clinical medicinebiology.proteinaineenvaihduntatuotteetkoe-eläinmallitSteatosismikro-RNAInternational Journal of Environmental Research and Public Health
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Gut microbiome and atrial fibrillation - results from a large population-based study

2023

Background Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown. Methods We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany. Findings Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 5…

rytmihäiriötmetagenomicsCardiovascular and Metabolic Diseasessuolistomikrobistosydän- ja verisuonitauditgut microbiomeatrial fibrillationepidemiologyriskitekijätepidemiologiaeteisvärinä
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Prebiotic Xylo-oligosaccharides Targeting Faecalibacterium prausnitzii Prevent High Fat Diet-induced Hepatic Steatosis in Rats

2020

Understanding the importance of gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat associated with low abundance of Faecalibacterium prausnitzii in humans and further, administration of F. prausnitzii prevented NAFLD in mice. Here, we aimed to target F. prausnitzii by prebiotic xylo-oligosaccharides (XOS) to treat NAFLD. First, the effect of XOS on F. prausnitzii growth was assessed in vitro. Then, XOS was supplemented or not with high (HFD) or low (LFD) fat-diet for 12-weeks in Wistar rats (n=10/group). XOS increased F. prausnitzii growth having only minor impact on the GM composition. When supp…

biologyChemistryPrebioticmedicine.medical_treatmentdigestive oral and skin physiologyFatty livergastroenterologynutritional and metabolic diseasesfood and beveragesFaecalibacterium prausnitziiHigh fat dietMetabolismGut floraMitochondrionmedicine.diseasebiology.organism_classificationdigestive system3. Good healthmedicineFood scienceSteatosis
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