0000000000709142
AUTHOR
Rodica Isaico
showing 5 related works from this author
Erythrocyte Phospholipid and Polyunsaturated Fatty Acid Composition in Diabetic Retinopathy
2014
Background: Long chain polyunsaturated fatty acids (LCPUFAs) including docosahexaenoic acid and arachidonic acid are suspected to play a key role in the pathogenesis of diabetes. LCPUFAs are known to be preferentially concentrated in specific phospholipids termed as plasmalogens. This study was aimed to highlight potential changes in the metabolism of phospholipids, and particularly plasmalogens, and LCPUFAs at various stages of diabetic retinopathy in humans. Methodology and Principal Findings: We performed lipidomic analyses on red blood cell membranes from controls and mainly type 2 diabetes mellitus patients with or without retinopathy. The fatty acid composition of erythrocytes was det…
Macular sensitivity and structure in idiopathic epiretinal membranes 12 months after surgical treatment
2013
Purpose: To evaluate macular sensitivity (MS) change and its correlation with visual acuity (VA) and Spectral-Domain Optical Coherence Tomography (SD-OCT) in patients with idiopathic epiretinal membrane (ERM) at 3, 6 and 12 months after surgical treatment.Methods: Prospective, monocenter, interventional case series. We included 49 patients (49 eyes) with an idiopathic ERM scheduled for a surgical treatment. Among these patients, 40 were evaluated at 3 and 6 months (M3, M6), and 31 at 12 months (M12) after ERM and internal limiting membrane removal. At each visit a measurement of best-corrected visual acuity (ETDRS), a microperimetry and a SD-OCT were performed for all patients.Results: The …
Polyunsaturated fatty acids and plasmalogens in diabetics
2013
PurposePlasmalogens are phospholipids characterized by a vinyl ether bond and a preferential esterification of polyunsaturated fatty acids (PUFA). We have previously shown that the lack of plasmalogens leads to retinal hyper-capillarization. We hypothesize that plasmalogens are negative regulators of vascular development, and aimed to check their circulating levels in diabetic patients with a retinopathy. MethodsBlood samples were collected from 88 patients and 14 control subjects. Among diabetics we had 14 patients without diabetic retinopathy (DR), 12 with a mild non proliferative DR, 12 with a moderate non proliferative DR, 22 with a severe non proliferative DR and 24 with a proliferativ…
Plasmalogen levels are reduced in erythrocytes from patients with diabetic retinopathy
2011
Plasmalogen levels are reduced in erythrocytes from patients with diabetic retinopathy. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)
Anatomic and functional follow-up of patients with an idiopathic epiretinal membrane and a preserved visual acuity
2013
Purpose: To determine the anatomic and functional retinal modifications in patients with an idiopathic epiretinal membrane (ERM) and a preserved visual acuity (VA).Methods: Monocentric, prospective study in 24 eyes of 24 patients with an ERM and a VA better than 20/25. Recorded data were best corrected VA on ETDRS scale, retinal anatomic lesions on spectral-domain OCT, retinal sensitivities on microperimetry and macular and foveal thicknesses at 0 and 6 months.Results: At inclusion, mean VA was 84 ± 5 letters, mean macular sensitivity was 14.0 ± 1.4 decibels (dB) and mean foveal sensitivity was 14,4 ± 1,5 dB. Mean macular thickness was 351 ± 34 µm and mean foveal thickness was 348 ± 66 µm. …