Effect of cadmium and manganese on gene expression and proliferative/invasive ability of tumoral and immortalized epithelial cells form the human breast

Histone Deacetylase Inhibitors

Histone deacetylases (HDACs) are key components of the epigenetic machinery controlling gene expression. They are involved in chromatin remodeling events via post-translational histone modifications but may also act on nonhistone proteins, influencing many fundamental cellular processes. Due to the key involvement of HDACs in serious human pathologies, including cancer, HDAC inhibitors (HDACis) have received increased attention in recent years. It is known that marine invertebrates produce significant amounts of secondary metabolites showing active pharmacological properties and an extensive spectrum of biomedical applications. Some of these compounds possess HDACi properties.

Il PTHrP [38-94]-amide è un fattore “DNA-binding”: dati citogenetica e molecolari ed effetto biologico su cellule epiteliali mammarie immortalizzate e neoplastiche

P38 MAPK pathway is involved in cadmium response by MDA-MB231 breast cancer cells