Author: C John

0000000000713500

AUTHOR

C John

showing 2 related works from this author

Variants associated with HHIP expression have sex-differential effects on lung function [version 1; peer review: 2 approved]

2020

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex on …

genome-wide interaction studyHHIPlcsh:Rlcsh:Medicinelung functiongenotyyppisukupuolihengityselimettoimintakykyexpressionsexlcsh:Qgeeniekspressiogeneettiset tekijätlcsh:SciencekeuhkotWellcome Open Research

researchProduct

Real-world efficacy of elbasvir/grazoprevir in HCV GT1 infected diabetics: results from the German Hepatitis C Registry

2020

Germanbusiness.industrymedicinelanguageElbasvir GrazoprevirHepatitis Cmedicine.diseasebusinessVirologylanguage.human_languageZeitschrift für Gastroenterologie

researchProduct

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