Chemotherapy for Urinary Bladder Cancer: Developments, Trends, and Future Perspectives

The role of chemotherapy in the management of transitional bladder tumors can conveniently be considered under two principal headings — topical (intracavitary) and sytemic chemotherapy, as the indications for these modalities are distinctly different. The intent of topical administration of cytoxic agents may be (1) prophylactic to prevent recurrences or new occurrences after TUR; (2) curative to clear the bladder of extensive non-resectable multifocal disease, or to control carcinoma in situ.