S68. UNALTERED FRONTAL AND PREFRONTAL BRAIN RESPONSE DURING WORK MEMORY TASKS IN PATIENTS WITH A FIRST EPISODE PSYCHOSIS META-ANALYSIS STUDY

2019

BACKGROUND: There is extensive evidence that frontal and prefrontal cortex have abnormal functioning in patients with schizophrenia (Weinberger et al., 2001). For example, with functional magnetic resonance imaging (fMRI), multiple studies have shown altered activation during working memory tasks in these patients compared with controls (Adamczyk et al., 2017; Li et al., 2017). While most of the studies have been conducted in patients with chronic illness, whether these findings translate to individuals at the time of presenting with a First Episode Psychosis (FEP) is less well understood (Soldevila-Matias et al., 2018). The main objective of this study was to meta-analyze fMRI studies that…