0000000000718060

AUTHOR

R. A. John Challiss

showing 3 related works from this author

Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3

2021

Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic age…

BradycardiaAtropinePilocarpineChemistryMuscarinic acetylcholine receptormedicinePharmacologymedicine.symptomMuscarinic AgentsEndogenous agonistAcetylcholinemedicine.drugAcetylcholine receptorIUPHAR/BPS Guide to Pharmacology CITE
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Acetylcholine receptors (muscarinic) in GtoPdb v.2021.2

2021

Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic age…

BradycardiaAtropineChemistryPilocarpineMuscarinic acetylcholine receptormedicinemedicine.symptomPharmacologyMuscarinic AgentsAcetylcholineEndogenous agonistmedicine.drugAcetylcholine receptorIUPHAR/BPS Guide to Pharmacology CITE
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Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019

Muscarinic acetylcholine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [45]) are GPCRs of the Class A, rhodopsin-like family where the endogenous agonist is acetylcholine. In addition to the agents listed in the table, AC-42, its structural analogues AC-260584 and 77-LH-28-1, N-desmethylclozapine, TBPB and LuAE51090 have been described as functionally selective agonists of the M1 receptor subtype via binding in a mode distinct from that utilized by non-selective agonists [243, 242, 253, 155, 154, 181, 137, 11, 230]. There are two pharmacologically characterised allosteric sites on muscarinic receptors, one defined by it binding gallami…

chemistry.chemical_compoundChemistryAllosteric regulationMuscarinic acetylcholine receptormedicineStrychnineMuscarinic acetylcholine receptor M1PharmacologyAcetylcholineEndogenous agonistmedicine.drugAcetylcholine receptorG protein-coupled receptorIUPHAR/BPS Guide to Pharmacology CITE
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