0000000000719343

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On Behalf Of The Binocolo Group

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Pneumococcal Colonization in the Familial Context and Implications for Anti-Pneumococcal Immunization in Adults: Results from the BINOCOLO Project in…

2017

The spread of Streptococcus pneumoniae within families has been scarcely investigated so far. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-aged children and co-habiting relatives and to explore the potential link between the family environment and the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of 146 subjects belonging to 36 different family groups were molecularly tested for pneumococcal detection and serotyping. The overall prevalence of pneumococcal carriage was 65.8% (n = 96/146), whereas it was higher among schoolchildren (77.8%, n = 28/36); subjects of seven years of age had the highest odds of being co…

0301 basic medicineSerotypeMalePediatricsfamilymedicine.disease_causeSettore MED/42 - Igiene Generale E ApplicataPneumococcal Vaccineslcsh:Chemistry0302 clinical medicineColonizationChild<i>Streptococcus pneumoniae</i>; conjugate vaccine; serotypes; schoolchildren; family; carriage; colonization; horizontal transmission; real-time PCRSicilylcsh:QH301-705.5SpectroscopyschoolchildrenGeneral MedicineMiddle AgedComputer Science ApplicationsStreptococcus pneumoniae030220 oncology & carcinogenesisChild Preschoolconjugate vaccinePopulation studyFemaleHorizontal transmissionAdultmedicine.medical_specialtyAdolescentContext (language use)CatalysisPneumococcal InfectionsArticleInorganic Chemistry03 medical and health sciencesYoung AdultSerotypeConjugate vaccineStreptococcus pneumoniaemedicineHumansPhysical and Theoretical ChemistrySerotypingMolecular BiologycarriageVaccines Conjugatebusiness.industryOrganic ChemistryOdds ratiohorizontal transmissioncolonization030104 developmental biologyserotypeslcsh:Biology (General)lcsh:QD1-999Feasibility StudiesImmunizationCarriage; Colonization; Conjugate vaccine; Family; Horizontal transmission; Real-time PCR; Schoolchildren; Serotypes; Streptococcus pneumoniaebusinessreal-time PCRDemographyInternational Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 105
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