0000000000740601

AUTHOR

Judith Bauer

showing 2 related works from this author

Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide

2012

Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hierarchical cluster analyses, Ingenuity signaling pathway analysis). Among the identified pathways were signaling routes for p53, integrin-linked kinase, and actin cytoskeleton. Genes from these pathways…

MicroarraysTumor PhysiologyCancer Treatmentlcsh:MedicineToxicologyArsenicalschemistry.chemical_compoundArsenic TrioxideBasic Cancer ResearchRNA NeoplasmArsenic trioxidelcsh:ScienceOligonucleotide Array Sequence AnalysisMultidisciplinaryintegumentary systemCytotoxinsOxidesTransfectionNeoplasm ProteinsGene Expression Regulation NeoplasticActin CytoskeletonOncologyMedicineThioredoxinSignal TransductionResearch Articleinorganic chemicalsAcute promyelocytic leukemiaToxic Agentschemistry.chemical_elementAntineoplastic AgentsBiologyComplementary and Alternative MedicineCell Line TumormedicineHumansRNA MessengerBiologyArseniclcsh:RComputational BiologyCancers and Neoplasmsmedicine.diseaseActin cytoskeletonMolecular biologychemistryDrug Resistance NeoplasmApoptosisCell culturelcsh:QPLoS ONE
researchProduct

Pharmacogenomic determination of genes associated with sensitivity or resistance of tumor cells to curcumin and curcumin derivatives

2010

Curcuma longa L. has long been used as a medicinal plant in traditional Chinese medicine against abdominal disorders. Its active constituent curcumin has anti-inflammatory, chemopreventive and cytotoxic properties. In the present investigation, we have analyzed the cytotoxic activity of curcumin and four derivatives. Among these compounds, ethoxycurcumintrithiadiazolaminomethylcarbonate was the most cytotoxic one. The curcumin-type compounds were not cross-resistant to standard anticancer drugs and were not involved in ATP-binding cassette transporter-mediated multidrug resistance. A combined approach of messenger RNA-based microarray profiling, COMPARE analyses and signaling pathway analys…

CurcuminEndocrinology Diabetes and MetabolismClinical BiochemistryAnti-Inflammatory AgentsATP-binding cassette transporterTraditional Chinese medicineDrug resistanceBiologyPharmacologyBiochemistrychemistry.chemical_compoundCell Line TumormedicineHumansCurcumaMolecular BiologyNutrition and DieteticsCancerbiology.organism_classificationmedicine.diseaseMultiple drug resistancechemistryDrug Resistance NeoplasmPharmacogeneticsPharmacogenomicsCurcuminATP-Binding Cassette TransportersThe Journal of Nutritional Biochemistry
researchProduct