0000000000741602
AUTHOR
A. D’andrea
Multiple hormonal and metabolic deficiency syndrome in chronic heart failure: rationale, design, and demographic characteristics of the T.O.S.CA. Registry.
Recent evidence supports the concept that progression of chronic heart failure (CHF) depends upon an imbalance of catabolic forces over the anabolic drive. In this regard, multiple hormonal deficiency syndrome (MHDS) significantly has impacts upon CHF progression, and is associated with a worse clinical status and increased mortality. The T.O.S.CA. (Trattamento Ormonale nello Scompenso CArdiaco; Hormone Therapy in Heart Failure) Registry (clinicaltrial.gov = NCT02335801) tests the hypothesis that anabolic deficiencies reduce survival in a large population of mild-to-moderate CHF patients. The T.O.S.CA. Registry is a prospective multicenter observational study coordinated by “Federico II” Un…
An algorithm based on the PPC (Polynomial Parametric Curve) for designing horizontal highway alignments
Criteria for geometric design of highway alignments have been studied in various researches so far, providing new methods, as alternative to traditional approaches. They can be useful for obtaining better solutions, characterized by high performances in terms of motion safety and comfort. In particular, continuous curvature alignments, based on polynomial functions, are highly consistent solutions with users' driving behaviour and vehicle trajectories. Moreover, alignment geometry optimization allows engineers to minimize dynamic effects on drivers with considerable advantages in terms of comfort and safety. This paper carries on the research of a previous study, in which a polynomial param…