0000000000744650

AUTHOR

Vincent A. Magnotta

showing 2 related works from this author

GLOBAL AND REGIONAL CORTICAL THINNING IN FIRST-EPISODE SCHIZOPHRENIA PATIENTS: RELATIONSHIPS WITH CLINICAL AND COGNITIVE FEATURES

2010

Psychiatry and Mental healthmedicine.medical_specialtyPhysical medicine and rehabilitationbusiness.industrymedicineCortical thinningCognitionFirst episode schizophreniabusinessBiological PsychiatrySchizophrenia Research
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Global and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features

2010

BackgroundThe thickness of the cortical mantle is a sensitive measure for identifying alterations in cortical structure. We aimed to explore whether first episode schizophrenia patients already show a significant cortical thinning and whether cortical thickness anomalies may significantly influence clinical and cognitive features.MethodWe investigated regional changes in cortical thickness in a large and heterogeneous sample of schizophrenia spectrum patients (n=142) at their first break of the illness and healthy controls (n=83). Magnetic resonance imaging brain scans (1.5 T) were obtained and images were analyzed by using brains2. The contribution of sociodemographic, cognitive and clinic…

AdultMalemedicine.medical_specialtyAdolescentbrainBrain mappingArticleYoung AdultCognitionCortex (anatomy)Internal medicineImage Processing Computer-AssistedmedicineHumansApplied PsychologyCerebral CortexPsychiatric Status Rating ScalesAnalysis of VarianceBrain Mappingmedicine.diagnostic_testAge FactorsMagnetic resonance imagingMiddle Agedcortical thicknessmedicine.diseaseMagnetic Resonance ImagingendophenotypeschizophreniaPsychiatry and Mental healthmedicine.anatomical_structureCerebral cortexSchizophreniaEndophenotypeCardiologyFemaleAnalysis of varianceAge of onsetPsychologyNeuroscienceMRIPsychological Medicine
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