0000000000745901

AUTHOR

Werner Paulus

showing 4 related works from this author

Contributions to the application of the transferability principle and the multipolar modeling of H atoms: electron-density study of L-histidinium dih…

2006

The electron density of L-histidinium dihydrogen orthophosphate orthophosphoric acid has been determined from X-ray and neutron diffraction data at low temperature (120 K). Topological analysis of the electron density has been used to analyse the effect of the multipolar refinement strategy on the electron-density model in the hydrogen-bonding regions. The electron density at low temperature has also been used to acquire high-quality experimental thermal parameters at room temperature using the transferability principle. Molecular vibrations, TLS and normal mode analysis are discussed and studied at both temperatures.

chemistry.chemical_compoundElectron densityCrystallographyStructural BiologyChemistryNormal modeHydrogen bondMolecular vibrationNeutron diffractionAnalytical chemistryCrystal structurePhosphoric acidTopology (chemistry)Acta crystallographica. Section A, Foundations of crystallography
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First German Guideline on Diagnostics and Therapy of Clinically Non-Functioning Pituitary Tumors

2021

AbstractAlthough non-functioning pituitary tumors are frequent, diagnostic and therapeutic concepts are not well standardized. We here present the first German multidisciplinary guideline on this topic. The single most important message is to manage the patients by a multidisciplinary team (consisting at least of an endocrinologist, a neurosurgeon, and a (neuro-) radiologist). The initial diagnostic work-up comprises a detailed characterization of both biochemical (focusing on hormonal excess or deficiency states) and morphological aspects (with magnetic resonance imaging of the sellar region). An ophthalmological examination is only needed in presence of symptoms or large tumors affecting …

medicine.medical_specialtyAdenomaEndocrinology Diabetes and Metabolismmedicine.medical_treatmentMedizin030209 endocrinology & metabolism03 medical and health sciencesTherapeutic approach0302 clinical medicineEndocrinologyGermanyInternal MedicinemedicineHumansPituitary NeoplasmsNeuroradiologyPatient Care Teammedicine.diagnostic_testbusiness.industryPituitary tumorsMagnetic resonance imagingGeneral MedicineGuidelinemedicine.diseaseMagnetic Resonance ImagingRadiation therapyPractice Guidelines as TopicRadiologyNeurosurgerybusiness030217 neurology & neurosurgeryExperimental and Clinical Endocrinology & Diabetes
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Predictive chromosomal clusters of synchronous and metachronous brain metastases in clear cell renal cell carcinoma

2014

Synchronous (early) and metachronous (late) brain metastasis (BM) events of sporadic clear cell renal cell carcinoma (ccRCC) (n = 148) were retrospectively analyzed using comparative genomic hybridization (CGH). Using oncogenetic tree models and cluster analyses, chromosomal imbalances related to recurrence-free survival until BM (RFS-BM) were analyzed. Losses at 9p and 9q appeared to be hallmarks of metachronous BM events, whereas an absence of detectable chromosomal changes at 3p was often associated with synchronous BM events. Correspondingly, k-means clustering showed that cluster 1 cases generally exhibited low copy number chromosomal changes that did not involve 3p. Cluster 2 cases ha…

AdultMaleCancer ResearchDNA Copy Number VariationsMedizinChromosome 9BiologySporadic Clear Cell Renal Cell Carcinoma03 medical and health sciences0302 clinical medicineGeneticsmedicineHumansCarcinoma Renal CellMolecular BiologyAgedRetrospective StudiesSequence Deletion030304 developmental biologyAged 80 and overChromosome AberrationsGeneticsComparative Genomic Hybridization0303 health sciencesBase SequenceBrain NeoplasmsChromosomeDNA NeoplasmMiddle Agedmedicine.diseaseKidney NeoplasmsClear cell renal cell carcinomaTumor progression030220 oncology & carcinogenesisCancer researchFemaleNeoplasm Recurrence LocalLow copy numberComparative genomic hybridizationBrain metastasisCancer Genetics
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Pediatric High-Grade Astrocytomas Show Chromosomal Imbalances Distinct from Adult Cases

2001

We studied 23 pediatric high-grade astrocytomas by comparative genomic hybridization. Chromosomal imbalances were found in 10 of 10 anaplastic astrocytomas and 11 of 13 glioblastomas and consisted of +1q (43%), +3q (26%), +1p, +2q, +5q (22%), −22q (34%), −6q, −10q (30%), −9q, −11q, −13q, −16q, and −17p (22%). Anaplastic astrocytomas frequently showed +5q (40%), +1q (30%), −22q (50%), −6q, −9q (40%), and −12q (30%); glioblastomas +1q (54%), +3q (38%), +2q, +17q (23%), −6q, −8q, −10q, −13q, and −17p (31%). Minimal common regions mapped to +1q21-41, +3q27-qter, +2q31-32, +5q14-22, −22q12-qter, −10q23-25, −6q25-qter, −9q34.2, −11q14−22, −16q22-qter, and −17p. High-level gains were located on 1q…

MalePathologymedicine.medical_specialtyAdolescentGene DosageAstrocytomaBiologyGastroenterologyPathology and Forensic MedicineInternal medicinemedicineHumansChildChromosome AberrationsBrain NeoplasmsInfantNucleic Acid HybridizationAstrocytomamedicine.diseaseSurvival AnalysisKi-67 AntigenChild PreschoolFemaleGlioblastomaCell DivisionRegular ArticlesGlioblastomaAnaplastic astrocytomaThe American Journal of Pathology
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