0000000000746158
AUTHOR
Montalto G.
The multifaceted spectrum of liver cirrhosis in older hospitalised patients: Analysis of the REPOSI registry
Abstract Background Knowledge on the main clinical and prognostic characteristics of older multimorbid subjects with liver cirrhosis (LC) admitted to acute medical wards is scarce. Objectives To estimate the prevalence of LC among older patients admitted to acute medical wards and to assess the main clinical characteristics of LC along with its association with major clinical outcomes and to explore the possibility that well-distinguished phenotypic profiles of LC have classificatory and prognostic properties. Methods A cohort of 6,193 older subjects hospitalised between 2010 and 2018 and included in the REPOSI registry was analysed. Results LC was diagnosed in 315 patients (5%). LC was ass…
Underdiagnosis and undertreatment of osteoporotic patients admitted in internal medicine wards in Italy between 2010 and 2016 (the REPOSI Register)
Purpose: To evaluate clinical features, treatments, and outcomes of osteoporotic patients admitted to internal medicine and geriatric wards compared with non-osteoporotic patients (REPOSI registry). Methods: We studied 4714 patients hospitalized between 2010 and 2016. We reported age, sex, educational level, living status, comorbidities and drugs taken, Cumulative Illness Rating Scale (CIRS), Barthel Index, Short-Blessed Test, 4-item Geriatric Depression Scale, serum hemoglobin, creatinine, and clinical outcomes. Osteoporosis was defined based on the diagnoses recorded at admission, according to the following ICD9: 733, 805-813, 820-823. Results: Twelve percent of the patients had a preadmi…
DRUG INDUCED LIVER INJURIES BY TICAGRELORSTATINS INTERACTION: A CASE REPORT
Background: The anti-aggregant therapy with aspirin and inhibitor of P2Y12 platelets receptor for ADP, such as ticagrelor, can be used to prevent atherothrombotic events in patients with coronaric acute syndrome. Statins are also recommended in these patients even if the safety profile is burdened by the risk of drug interaction (CYP 3A4 inhibition by ticagrelor). Here, we report a case of acute rabdomiolysis and hepatotoxicity in a woman with a recent myocardial infarction treated with ticagrelor 90 mg twice daily, aspirin 100 mg daily, atorvastatina 40 mg once daily. Methods: We report a case of 68 old Caucasian woman with a diagnosis of myocardial infarction and coronary percutaneous ste…