0000000000746479

AUTHOR

Marco Valenti

showing 8 related works from this author

Personalized Symptom Goals and Patient Global Impression on Clinical Changes in Advanced Cancer Patients.

2018

Abstract Background The aim of this study was to assess the patients’ global impression (PGI) after symptom management, as well as the achievement of personalized symptom goals (PSG). The secondary outcome was to assess related factors. Subjects, Materials, and Methods Advanced cancer patients admitted to palliative care units rated symptom intensity by using the Edmonton Symptom Assessment Score (ESAS) at admission and then after 1 week. For each symptom, patient-reported PGI and PSG, as well as the rate of PSG response, were evaluated. Results Eight hundred seventy-six patients were taken into consideration for this study. A mean of 1.71–2.16 points was necessary to perceive a bit better …

MaleCancer Researchmedicine.medical_specialtyMultivariate analysisPalliative careSymptom assessmentGlobal impression of change03 medical and health sciences0302 clinical medicineIntervention (counseling)Advanced cancerNeoplasmsmedicineOdd ratioHumans030212 general & internal medicineRelated factorsSymptom managementbusiness.industryAdvanced cancer; Global impression of change; Palliative care; Personalized symptom goal; Symptom assessmentAdvanced cancerOncologySymptom Management and Supportive Care030220 oncology & carcinogenesisPersonalized symptom goalPhysical therapyPalliative careFemaleSymptom AssessmentbusinessThe oncologist
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Pattern of symptoms and symptomatic treatment in adults and the aged population: a retrospective analysis of advanced cancer patients followed at hom…

2016

Context Data regarding symptom burden and symptomatic drugs in palliative population in different classes of age are lacking. Objective The aim of this retrospective study was to assess the symptom burden, and the profile of symptomatic drugs in the last four weeks of life in adults and older cancer patients followed at home. Methods Charts of 412 patients were retrospectively analyzed by using a backward analysis. Patients were divided into three groups: adults (<65 years, A), old (65-74 years, O1), very old (75-84 years, O2), and the oldest (≥85 years, O3). Results At -4W Karnofsky status was significantly lower for older people (p = 0.03). No significant effect of age on the vector of sy…

AdultMalePediatricsmedicine.medical_specialtyPalliative careNauseaPopulationSymptomatic treatmentPainHome care03 medical and health sciences0302 clinical medicineElderlyAdvanced cancerNeoplasmsRetrospective analysisOld patientsMedicineHumans030212 general & internal medicineAdvanced cancer; Drugs; Elderly; Home care; Old patients; Palliative care; Symptoms; Medicine (all)Karnofsky Performance StatuseducationAgedRetrospective StudiesAged 80 and overeducation.field_of_studybusiness.industryMedicine (all)Anti-Inflammatory Agents Non-SteroidalAge FactorsCancerDrugsRetrospective cohort studyNauseaGeneral MedicineMiddle Agedmedicine.diseaseAdvanced cancerHome Care ServicesAnalgesics Opioid030220 oncology & carcinogenesisSymptomsPalliative careAntiemeticsFemalemedicine.symptombusinessCurrent medical research and opinion
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Sleep Disturbances in Patients with Advanced Cancer in Different Palliative Care Settings.

2015

Abstract Context Information regarding sleep disturbances in the population with advanced cancer is meager. Objectives To assess the prevalence of sleep disturbances and possible correlations with associated factors in a large number of patients with advanced cancer admitted to different palliative care settings. Methods This was an observational study performed in different settings of palliative care. A consecutive sample of patients with advanced cancer was prospectively assessed for a period of six months. Epidemiological and clinical data, treatments received in the last month, Karnofsky status, Edmonton Symptom Assessment System scores, and concomitant medical treatment were recorded.…

medicine.medical_specialtyPediatricsPalliative careCross-sectional studyinsomniaPopulationSleep disturbanceadvanced cancer; insomnia; palliative care; Sleep disturbances; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)Sleep Wake DisordersHospital Anxiety and Depression ScalemedicineInsomniaadvanced cancerAthens insomnia scaleeducationProspective cohort studyGeneral NursingNursing (all)2901 Nursing (miscellaneous)education.field_of_studypalliative carebusiness.industrySleep disturbancesAnesthesiology and Pain MedicinePhysical therapyNeurology (clinical)medicine.symptombusiness
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Adult-onset Still’s disease: evaluation of prognostic tools and validation of the systemic score by analysis of 100 cases from three centers

2016

Background: Adult-onset Still's disease (AOSD) is rare inflammatory disease of unknown etiology that usually affects young adults. The more common clinical manifestations are spiking fevers, arthritis, evanescent rash, elevated liver enzymes, lymphadenopathy, hepatosplenomegaly, and serositis. The multi-visceral involvement of the disease and the different complications, such as macrophage activation syndrome, may strongly decrease the life expectancy of AOSD patients. Methods: This study aimed to identify the positive and negative features correlated with the outcome of patients. A retrospective analysis of AOSD patients prospectively admitted to three rheumatologic centers was performed t…

AdultMale0301 basic medicinemedicine.medical_specialtyPrognosiHepatosplenomegalyArthritisDiseaseAdult-onset Still's diseaseYoung Adult03 medical and health sciencesSystemic score0302 clinical medicineRetrospective StudieInternal medicinemedicineHumansYoung adultRetrospective StudiesAdult-onset Still’s diseaseMedicine(all)030203 arthritis & rheumatologyPrognostic factorbusiness.industryMedicine (all)BiomarkerGeneral MedicineMiddle AgedPrognosismedicine.diseaseRashSurgerySettore MED/16 - Reumatologia030104 developmental biologyMacrophage activation syndromeMacrophage activation syndromeEtiologyAdult-onset Still’s disease; Macrophage activation syndrome; Prognostic factor; Systemic scoreFemalemedicine.symptombusinessStill's Disease Adult-OnsetSerositisBiomarkersHumanResearch ArticleBMC Medicine
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FRI0504 Prognostic Factors of Adult Onset Still's Disease: Analysis of 100 Cases in 3 Tertiary Referral Centers

2016

Background Adult onset Still9s disease (AOSD) is rare inflammatory disease [1]. Three different patterns of AOSD have been identified: i. monocyclic pattern, characterized by a systemic single episode; ii. polycyclic pattern, associated with multiple flares, separated by remissions; iii. chronic pattern, related to a persistently active disease with associated polyarthritis [2]. Until now, the treatment of AOSD remains largely empirical, lacking controlled clinical trials [1]. Objectives We aimed to investigate clinical data of AOSD patients and any possible correlation among these features and the outcome of patients. Methods Clinical data of 100 AOSD patients were recorded. All patients f…

medicine.medical_specialtyImmunologyArthritisGeneral Biochemistry Genetics and Molecular Biology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineTocilizumabRheumatologyInternal medicinemedicineImmunology and Allergy030212 general & internal medicine030203 arthritis & rheumatologyAnakinramedicine.diagnostic_testbusiness.industrymedicine.diseaseRashSurgerychemistryErythrocyte sedimentation rateMacrophage activation syndromePolyarthritismedicine.symptombusinessComplicationmedicine.drugAnnals of the Rheumatic Diseases
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Prognostic factors of macrophage activation syndrome, at the time of diagnosis, in adult patients affected by autoimmune disease: Analysis of 41 case…

2016

Macrophage activation syndrome (MAS) is a rare, life-threatening disease in which early diagnosis and aggressive therapeutic strategy may improve the outcome. Due to its rarity, epidemiologic data are still lacking. Hyperferritinemia is frequently associated with MAS and might modulate the cytokine storm, which is involved in the development of multiple organ failure. In this paper, we investigated clinical data, treatments, and outcome of a homogeneous cohort of 41 adult MAS patients, complicating autoimmune rheumatic diseases. MAS-related death occurred in 17 patients (42.5%) during the follow-up, and older age and increased serum ferritin levels, at the time of diagnosis, were significan…

AdultMalemusculoskeletal diseases0301 basic medicinemedicine.medical_specialtyImmunologyAdult onset Still's disease; Hyperferritinemic syndrome; Macrophage activation syndrome; Adult; Ambulatory Care Facilities; Autoimmune Diseases; Female; Humans; Immunosuppressive Agents; Macrophage Activation Syndrome; Male; Middle Aged; Prognosis; Retrospective Studies; Treatment Outcome; Immunology and Allergy; ImmunologyDiseaseAmbulatory Care FacilitiesAutoimmune Diseases03 medical and health sciences0302 clinical medicineAdult onset Still's diseaseInternal medicineHumansImmunology and AllergyMedicineRetrospective Studies030203 arthritis & rheumatologyAutoimmune diseaseAdult patientsbusiness.industryMortality ratefungiRetrospective cohort studyMiddle AgedPrognosisHyperferritinemic syndromemedicine.diseasebody regionsSettore MED/16 - ReumatologiaTreatment Outcome030104 developmental biologyMacrophage activation syndromeMacrophage activation syndromeCohortImmunologyFemalelipids (amino acids peptides and proteins)businessCytokine stormImmunosuppressive Agentshormones hormone substitutes and hormone antagonistsAutoimmunity Reviews
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Epidemiology and Characteristics of Episodic Breathlessness in Advanced Cancer Patients. An Observational Study

2016

Abstract Context Episodic breathlessness is a relevant aspect in patients with advanced cancer. Objectives The aim of this study was to assess the different aspects of this clinical phenomenon. Methods A consecutive sample of patients with advanced cancer admitted to different settings for a period of six months was surveyed. The presence of background breathlessness and episodic breathlessness, their intensity (numerical scale 0–10), and drugs used for treatment were collected. Factors inducing episodic breathlessness and its influence on daily activities were investigated. Results Of 921 patients, 29.3% ( n  = 269) had breathlessness and 134 patients (49.8%) were receiving drugs for backg…

MalePediatricsmedicine.medical_specialtyPalliative careActivities of daily livingTime FactorsEpisodic breathlessneSettore MED/41 - AnestesiologiaContext (language use)advanced cancer; dyspnea; Episodic breathlessness; opioids; palliative care; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)DiseaseComorbidityepisodic breathlessness; advanced cancer; dyspnea; opioids; palliative care03 medical and health sciencesPulmonary Disease Chronic Obstructive0302 clinical medicineNeoplasmsEpidemiologyActivities of Daily LivingmedicinePrevalenceHumansadvanced cancer030212 general & internal medicineKarnofsky Performance StatusGeneral NursingNursing (all)2901 Nursing (miscellaneous)Agedpalliative careEpisodic breathlessnessbusiness.industryEpisodic breathlessness; advanced cancer; dyspnea; opioids; palliative careopioidsCardiovascular Agentsrespiratory systemMiddle Ageddyspneamedicine.diseaseComorbidityAnesthesiology and Pain Medicine030220 oncology & carcinogenesisCardiovascular agentMultivariate AnalysisopioidObservational studyFemaleNeurology (clinical)business
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Assessing the risk of osteonecrosis of the jaw due to bisphosphonate therapy in the secondary prevention of osteoporotic fractures

2012

There is evidence that the use oral bisphosphonates can lead to osteronecrosis of the jaws (ONJ). Although the occurrence of ONJ appears rare among oral bisphosphonates (BPs) users, it is important to know that it exists and can be opportunely minimized. INTRODUCTION: The purpose of this study is to evaluate the association between BPs prescribed for the secondary prevention of osteoporotic fractures and the occurrence of ONJ. METHODS: An Italian record linkage claims database with a target population of around 18 million individuals (6 million over 55 years of age) constituted the data source. We conducted a nested case-control study within a cohort of individuals aged 55+ years old, who w…

Malemedicine.medical_specialtyEndocrinology Diabetes and MetabolismONJDentistryOsteoporosis; fractures; biphosphonatesAdministration OralBisphosphonates Nested case–control study Osteonecrosis of the jaw Osteoporotic fracturesOSTEPOROSISRisk AssessmentAssociationADMINSTRATIVE DATABASESnested case-control studySettore MED/28 - Malattie OdontostomatologicheClaims dataMedicineHumansnested case-control study; osteoporotic fractures; osteonecrosis of the jaw; bisphosphonatesWomenbisphosphonatesAgedSecondary preventionAged 80 and overOral bisphosphonatesBone Density Conservation AgentsDiphosphonatesbusiness.industryMiddle Agedmedicine.diseaseOral BisphosphonateNecrosiosteonecrosis of the jawItalyClaims DataCase-Control StudiesOrthopedic surgeryBisphosphonates; Osteonecrosis of the jaw; Osteoporotic fractures; Nested case-control studyBisphosphonate-Associated Osteonecrosis of the JawFemaleSurgeryProfileBisphosphonate therapyMedical Record LinkagebusinessOsteonecrosis of the jawOsteoporotic Fractures
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