0000000000749635
AUTHOR
Stephanie Njau
showing 2 related works from this author
Denoising of MR spectroscopy signals using total variation and iterative Gauss-Seidel gradient updates
2015
We present a fast variational approach for denoising signals from magnetic resonance spectroscopy (MRS). Differently from the TV approaches applied to denoising of images, this is the first time to our knowledge that it has been used for the processing of free induction decay signals from single-voxel spectroscopy (SVS) acquisitions. Another novelty in this study is the direct use of the Euler Lagrange formulation coupled with Gauss Seidel gradient updates to improve the speed of iteration and reduce ringing. Results from brain MRS signals show improvement in signal to noise ratio as well as reduction in estimation error in the quantification of metabolites.
Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression
2016
Background: Electroconvulsive therapy (ECT) is a highly effective brain stimulation treatment for severe depression. Identifying neurochemical changes linked with ECT may point to biomarkers and predictors of successful treatment response. Methods: We used proton magnetic resonance spectroscopy (1H-MRS) to measure longitudinal changes in glutamate/glutamine (Glx), creatine (Cre), choline (Cho) and N-acetylaspartate (NAA) in the dorsal (dACC) and subgenual anterior cingulate cortex (sgACC) and bilateral hippocampus in patients receiving ECT scanned at baseline, after the second ECT session and after the ECT treatment series. Patients were compared with demographically similar controls at bas…