Author: Hailin Jia

0000000000752212

AUTHOR

Hailin Jia

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Differential Expression Profiles and Functional Prediction of Circular RNAs in Pediatric Dilated Cardiomyopathy

2020

Circular RNAs (circRNAs) have emerged as essential regulators and biomarkers in various diseases. To assess the different expression levels of circRNAs in pediatric dilated cardiomyopathy (PDCM) and explore their biological and mechanistic significance, we used RNA microarrays to identify differentially expressed circRNAs between three children diagnosed with PDCM and three healthy age-matched volunteers. The biological function of circRNAs was assessed with a circRNA–microRNA (miRNA)–mRNA interaction network constructed from Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Differentially expressed circRNAs were validated by quantitative real-time polymerase chain reaction (qR…

0301 basic medicinecircular RNAs (circRNAs)gene expression profile (GEP)Microarray030204 cardiovascular system & hematologyBiologyBioinformaticsmedicine.disease_causeBiochemistry Genetics and Molecular Biology (miscellaneous)Biochemistrylaw.inventionAutoimmunity03 medical and health sciences0302 clinical medicinepediatric dilated cardiomyopathylawmicroRNAmedicineMolecular BiosciencesKEGGMolecular Biologylcsh:QH301-705.5Polymerase chain reactionOriginal ResearchRNAbiomarkersFold change030104 developmental biologylcsh:Biology (General)DNA microarraymicroarrayFrontiers in Molecular Biosciences

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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LSLife Sciences
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SHSocial Sciences and Humanities
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