0000000000754988

AUTHOR

Christopher Bowd

showing 5 related works from this author

Macula structural and vascular differences in glaucoma eyes with and without high axial myopia

2021

AbstractAimsTo assess the thickness of various retinal layers, and the superficial vessel density (sVD) in the macula of glaucomatous eyes and their associations with axial length (AL) and visual field mean deviation (VFMD) to identify parameters useful for glaucoma management in myopic eyes.Methods248 glaucoma patients (401 eyes) participating in the Diagnostic Innovations in Glaucoma Study observational cohort representing 3 axial myopia groups (non-myopia: n=146 eyes; mild myopia: n=208 eyes; high myopia (AL>26 mm): n=47 eyes) who completed macular OCT and OCT-Angiography imaging were included. The cross-sectional associations of AL and VFMD with the thickness of the ganglion cell inn…

medicine.medical_specialtygenetic structuresbusiness.industryNerve fiber layerGlaucomaRetinalmedicine.diseaseInner plexiform layereye diseasesGanglionVisual fieldchemistry.chemical_compoundmedicine.anatomical_structurechemistryOphthalmologymedicineWeak associationsense organsbusinessAxial myopia
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Effects of Study Population, Labeling and Training on Glaucoma Detection Using Deep Learning Algorithms

2020

Author(s): Christopher, Mark; Nakahara, Kenichi; Bowd, Christopher; Proudfoot, James A; Belghith, Akram; Goldbaum, Michael H; Rezapour, Jasmin; Weinreb, Robert N; Fazio, Massimo A; Girkin, Christopher A; Liebmann, Jeffrey M; De Moraes, Gustavo; Murata, Hiroshi; Tokumo, Kana; Shibata, Naoto; Fujino, Yuri; Matsuura, Masato; Kiuchi, Yoshiaki; Tanito, Masaki; Asaoka, Ryo; Zangwill, Linda M | Abstract: PurposeTo compare performance of independently developed deep learning algorithms for detecting glaucoma from fundus photographs and to evaluate strategies for incorporating new data into models.MethodsTwo fundus photograph datasets from the Diagnostic Innovations in Glaucoma Study/African Descent…

0301 basic medicineAginggenetic structuresFundus OculiAfrican descentPopulationBiomedical EngineeringGlaucomaPrimary careNeurodegenerativeoptic disc03 medical and health sciences0302 clinical medicineDeep LearningOpthalmology and OptometryArtificial IntelligencemedicineHumanseducationMild diseaseeducation.field_of_studyReceiver operating characteristicbusiness.industrySpecial IssueDeep learningimagingartificial intelligencemedicine.diseaseeye diseasesOphthalmology030104 developmental biologyglaucomamachine learning030221 ophthalmology & optometryPopulation studyArtificial intelligencebusinessPsychologyAlgorithmAlgorithmsTranslational Vision Science & Technology
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Intereye Spatial Relationship of Abnormal Neuroretinal Rim Locations in Glaucoma Patients from the Diagnostic Innovations in Glaucoma Study

2006

Purpose To determine the spatial relationship in neuroretinal rim parameter values between eyes in ocular hypertensives, glaucoma suspects, and glaucoma patients. Design Observational-cross-sectional study. Methods A total of 334 eyes of 167 patients were included. All patients underwent confocal scanning laser ophthalmoscopy imaging in both eyes. Intereye concordance ratio of abnormal rim sectors as classified by the Moorfield regression analysis (MRA) was calculated as the ratio of matching abnormal rim areas to the total number of abnormal rim areas. The amount of agreement was calculated for each sector separately. Results Of the right (left) eyes, 39 (39) eyes were classified “borderli…

MaleRetinal Ganglion Cellsmedicine.medical_specialtyIntraocular pressuregenetic structuresConcordanceOptic DiskVision DisordersGlaucomaOphthalmoscopyNerve FibersOphthalmologyOptic Nerve DiseasesmedicineHumansProspective StudiesProspective cohort studyIntraocular PressureAgedmedicine.diagnostic_testbusiness.industryLasersMiddle Agedmedicine.diseaseeye diseasesOphthalmoscopyOphthalmologyCross-Sectional StudiesNeuroretinal rimDisease ProgressionOptometryFemaleOcular Hypertensionsense organsVisual FieldsAbnormalitybusinessGlaucoma Open-AngleKappaAmerican Journal of Ophthalmology
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Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics Based on Thickness Maps from Macula OCT.

2021

Purpose To develop deep learning (DL) systems estimating visual function from macula-centered spectral-domain (SD) OCT images. Design Evaluation of a diagnostic technology. Participants A total of 2408 10-2 visual field (VF) SD OCT pairs and 2999 24-2 VF SD OCT pairs collected from 645 healthy and glaucoma subjects (1222 eyes). Methods Deep learning models were trained on thickness maps from Spectralis macula SD OCT to estimate 10-2 and 24-2 VF mean deviation (MD) and pattern standard deviation (PSD). Individual and combined DL models were trained using thickness data from 6 layers (retinal nerve fiber layer [RNFL], ganglion cell layer [GCL], inner plexiform layer [IPL], ganglion cell-IPL […

MaleDesign evaluationGlaucoma03 medical and health sciences0302 clinical medicinePattern standard deviationDeep LearningLinear regressionDiagnostic technologyMedicineHumansMacula LuteaIntraocular Pressure030304 developmental biologyAged0303 health sciencesbusiness.industryOutcome measuresGlaucomaMiddle Agedmedicine.diseaseConfidence intervalVisual fieldOphthalmologyBenchmarkingCross-Sectional Studies030221 ophthalmology & optometryFemaleVisual FieldsbusinessNuclear medicineTomography Optical CoherenceFollow-Up StudiesOphthalmology
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Agreement among 3 optical imaging methods for the assessment of optic disc topography.

2005

Purpose To assess the agreement of disc topography measurements between the Heidelberg Retina Tomograph (HRT II), Retinal Thickness Analyzer (RTA), and Optical Coherence Tomograph (StratusOCT). Design Observational cross-sectional study. Participants Forty-two randomly chosen eyes of 42 subjects. Methods Each subject underwent HRT II, RTA, and StratusOCT examination. Two experienced examiners drew the contour lines for the HRT II and RTA. Bland and Altman plots were used to evaluate agreement for each topographic parameter among the instruments. The Spearman coefficient of rank correlation was evaluated for each topographic parameter. Main Outcome Measures Agreement in the measurement of op…

Diagnostic ImagingMaleRetinal Ganglion Cellsmedicine.medical_specialtygenetic structuresOptic DiskGlaucomaSpearman's rank correlation coefficientRetinal thickness analyzerOptical imagingNerve FibersOphthalmologyLinear regressionOptic Nerve DiseasesMedicineHumansIntraocular PressureRank correlationAgedRetrospective Studiesbusiness.industryReproducibility of ResultsMiddle Agedmedicine.diseaseeye diseasesOphthalmologymedicine.anatomical_structureCross-Sectional StudiesFemalesense organsTomographybusinessGlaucoma Open-AngleOptic discOphthalmology
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