Effects of the clinical characteristics of the organ donor on the long-term results of the transplant and survival of the patient, with particular re…

2007

To assess the role of the single clinical parameters of the donor on the outcome of the transplant and the variability of this in relation to the state of an optimal or borderline donor.

Platelet Function Changes In Acute Myocardial Infarction

1981

Whether the thrombotic component of myocardial infarction is primary or secondary in a given patient, platelet function alterations can influence many mechanism from which depends if the thrombotic lesion grows or sends platelet emboli to the smaller myocardial vessels. Recently in some cases of infarction, coronary artery spasm has been demonstrated angiographically; thromboxanes, vasoconstrictive and platelet-aggregating substances, are released by platelets during myocardial ischemia. The local release of these substances may modify the myocardial cell viability and regional blood flow.The aim of the present study was to investigate changes in platelet function in relation to the time in…

HCV NS3 sequencing as a reliable and clinically useful tool for the assessment of genotype and resistance mutations for clinical samples with differe…

2016

OBJECTIVES: This study aims to evaluate the reliability and clinical utility of NS3 sequencing in hepatitis C virus (HCV) 1-infected patients who were candidates to start a PI-containing regimen. METHODS: NS3 protease sequencing was performed by in-house-developed HCV-1 subtype-specific protocols. Phylogenetic analysis was used to test sequencing reliability and concordance with previous genotype/subtype assignment by commercial genotyping assays. RESULTS: Five hundred and sixty-seven HCV plasma samples with quantifiable HCV-RNA from 326 HCV-infected patients were collected between 2011 and 2014. Overall, the success rate of NS3 sequencing was 88.9%. The success rate between the two subtype…

Picco di massa ossea ed attività fisica: confronto tra giovani adulti sedentari, attivi e atleti

2009

OBIETTIVO - Valutare, nel periodo di raggiungimento del picco di massa ossea, gli effetti dell’attività fisica sulla mineralizzazione ossea in età giovanile. MATERIALI E METODI - Allo studio hanno partecipato 43 soggetti maschi, sani, con età media di 25 anni, suddivisi in tre gruppi in relazione all’intensità dell’attività fisica svolta dall’età di dieci anni in poi: il primo composto da 17 soggetti sedentari, il secondo da 16 soggetti attivi e il terzo da 15 soggetti atleti. Ogni soggetto è stato sottoposto a mineralometria ossea computerizzata (DEXA). La misurazione della densità ossea (BMD, g/cm2) dei soggetti ha riguardato: corpo intero (Total Body), collo femore dx e sx e tratto rachi…

Methylenetetrahydrofolate reductase homozygosis and low-density lipoproteins in patients with genotype 1 chronic hepatitis C

2012

Methylenetetrahydrofolate reductase status, homocysteine and lipoproteins levels have been associated with severity of disease and both rapid and sustained virological response (SVR) in patients with genotype 1 chronic hepatitis C (CHC). We aimed to assess the association of homocysteine and MTHFR status with serum cholesterol levels and their potential links to both histological findings and virological response, in patients with genotype 1 hepatitis C virus (HCV). A total of 119 consecutive patients were evaluated by biopsy and metabolic measurements. A total of 103 healthy blood donors were used as controls. Serum homocysteine and MTHFR C677T mutation were also evaluated. All patients un…

LOW VITAMIN D SERUM LEVEL IS RELATED TO RAPID, EARLY AND SUSTAINED VIROLOGICAL RESPONSE TO IFN-BASED THERAPY IN GENOTYPE 1 CHRONIC HEPATITIS C

2011