Author: Peter Körtvelyessy

0000000000757609

AUTHOR

Peter Körtvelyessy

showing 1 related works from this author

Biomarkers of Neurodegeneration in Autoimmune-Mediated Encephalitis

2018

Progranulin (PGRN), Total-Tau (t-tau), and Neurofilament light chain (NfL) are well known biomarkers of neurodegeneration. The objective of the present study was to investigate whether these parameters represent also biomarkers in autoimmune-mediated Encephalitis (AE) and may give us insights into the pathomechanisms of AE. We retrospectively examined the concentration of PGRN in the cerebrospinal fluid (CSF) and serum of 38 patients suffering from AE in acute phase and/or under treatment. This AE cohort comprises patients with autoantibodies against: NMDAR (n = 18 patients), Caspr2 (n = 8), Lgi-1 (n = 10), GABAB(R) (n = 1), and AMPAR (n = 1). Additionally, the concentrations of NfL (n = 25…

0301 basic medicinemedicine.medical_specialtyCaspr2 encephalitisLgi-1 encephalitisNMDAR encephalitisGastroenterologyCaspr2 encephalitis; Lgi-1 encephalitis; NMDAR encephalitis; autoimmune encephalitis; neurofilament light chain; progranulin; taulcsh:RC346-429Faculty of Medicine03 medical and health sciences0302 clinical medicineCerebrospinal fluidModified Rankin ScaleMedizinische FakultätInternal medicineprogranulinMedicineddc:6ddc:610taulcsh:Neurology. Diseases of the nervous systemOriginal ResearchAutoimmune encephalitisHippocampal sclerosisbusiness.industryNeurodegenerationAutoantibodyarticleNMDAR encephalitis ; neurofilament light chain ; Caspr2 encephalitis ; autoimmune encephalitis ; progranulin ; Lgi-1 encephalitis ; taumedicine.diseaseautoimmune encephalitis030104 developmental biologyneurofilament light chainNeurologyBiomarker (medicine)Neurology (clinical)business030217 neurology & neurosurgeryEncephalitis

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