Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

The majority of mortality associated with cancer is due to formation of metastases from the primary tumor. Adhesion mediated by different integrin heterodimers has an important role during cell migration and invasion. Protein interactions with the β1-integrin cytoplasmic tail are known to influence integrin affinity for extracellular ligands, but regulating binding partners for the α-subunit cytoplasmic tails have remained elusive. In this study, we show that mammary-derived growth inhibitor (MDGI) (also known as FABP-3 or H-FABP) binds directly to the cytoplasmic tail of integrin α-subunits and its expression inhibits integrin activity. In breast cancer cell lines, MDGI expression correlat…

Liikunta ja terveys: monivalintatestin laadinta

Designing a Eustress Toolbox : From entrepreneur experiences to an online service

Stress is typically seen as a negative phenomenon. However, the positive side of stress (i.e., eustress) has the potential to improve well-being, productivity, and innovativeness, thus increasing individuals’ daily resources at work. Focusing on eustress could enhance work engagement by turning some of the negatively perceived stressors into positive challenges. We explored this possibility by interviewing 21 Finnish entrepreneurs from various fields regarding their experiences of eustress. Nine of the interviewed entrepreneurs also recorded a eustress diary. Based on thematic analysis of the interview data, six main themes supporting eustress were identified: (a) Selfreflection toward chan…