0000000000758342
AUTHOR
Rocca R.
Ceci n'est pas une ontologie
The opening remarks of the Tractatus Logico-Philosophicus seem to outline the bases of an atomistic ontological theory. For the resolute interpreters, such an ontology should be considered as mere part of the set of nonsensical propositions that make up the parody of a semantic theory. However, resolute readers share with the traditional views an essentialist reading of the ontological section, according to which Wittgenstein's remarks are intended to build up a real, though parodistic, atomistic ontology. By contrast, textual evidence supports the idea that the basic notion of Wittgenstein’s ontology, i.e. the notion of object, should be considered as an intra-linguistic, rather t…
Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas
Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts to develop new therapeutic strategies. Our previous studies on pyrrole-based anti-lymphoma agents led us to synthesize a new series of twenty-six pyrrolo[3′,4':3,4]cyclohepta[1,2-d] [1,2]oxazole derivatives and study their antiproliferative effects against a panel of four non-Hodgkin lymphoma cell lines. Several candidates showed significant anti-proliferative effects, with IC50's reaching the sub-micromolar range in at least one cell line, with compound 3z demonstrating sub-micromolar growth inhibitory effects towards the entire panel. The VL51 cell line was the most sensitive, with an IC50 value of…