0000000000760074
AUTHOR
Martini S.
Positioning of darunavir/cobicistat-containing antiretroviral regimens in real life: results from a large multicentre observational prospective cohort (SCOLTA).
Abstract Background Study aim was to evaluate the safety and durability of darunavir/cobicistat (DRV/c) in a real life setting. Methods Multicentre prospective cohort study performed in the context of SCOLTA (Surveillance Cohort Long-Term Toxicity Antiretrovirals). Patients were evaluated at baseline, week 24 and 48. Changes were evaluated using the paired t test or signed rank test. The multivariable analysis was performed using a general linear model, after ranking of not normally distributed variables. Results A total of 249 patients were included, 72 (29%) were in DRV/c-based dual therapies (DT). Hypercholesterolemia, HC, (total cholesterol (TC) ≥ 200 mg/dL or low density-C (LDL-C) ≥ 13…
Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade
Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group - SIMOne, HIV-HY and STOPSHIV - and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equatio…
Neutrinos from GRBs with ANTARES
A search for muon neutrinos in coincidence with gamma-ray bursts with the ANTARES neutrino detector using data from the end of 2007 to 2011 is performed. Expected neutrino fluxes are calculated for each burst individually. The most recent numerical calculations of the spectra using the NeuCosmA code are employed, which include Monte Carlo simulations of the full underlying photohadronic interaction processes. The discovery probability for a selection of 296 gamma-ray bursts in the given period is optimised using an extended maximum-likelihood strategy. No significant excess over background is found in the data, and 90% confidence level upper limits are placed on the total expected flux acco…